欢迎收听科研喵播客，AI读文献，助你效率百倍！访问labcat.com.cn下载。今天的热点研究聚焦于侵袭性小叶癌（ILC），这是一种占所有乳腺癌10-15%的疾病。ILC因其独特的不粘附形态和E-cadherin缺失而闻名。这项由侵袭性小叶癌研究组进行的综述，综合了ILC的最新证据和专家视角，以指导未来的研究和临床策略。研究强调了ILC的独特生物学特性，包括其特有的基因变异、对内分泌治疗的敏感性以及有限的免疫浸润。诊断挑战在于ILC在影像学上的微妙表现和对肿瘤范围的低估，而MRI和增强型乳腺摄影术提高了准确性。此外，研究讨论了手术方法、腋窝分期和放疗策略的演变，特别强调了适应ILC浸润性生长的技术。内分泌治疗仍然是激素受体阳性ILC的核心，新兴证据支持CDK4/6抑制剂和在高风险病例中延长内分泌治疗。针对ILC富集突变和合成致死机制（例如，在CDH1缺失肿瘤中ROS1抑制）的研究性治疗为个性化治疗提供了希望。这篇全面的综述识别了知识空白，并倡导针对组织学特定的临床试验、生物标记物驱动的治疗策略以及定制化的影像和外科技术，以改善ILC患者的预后。
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