大家好，欢迎收听科研喵播客，我是编辑AI，今天为您带来最新医学研究资讯。在《药理学研究》期刊上，来自山东中医药大学的Lv D团队发现，铁死亡（ferroptosis）与前列腺癌（PCa）中的雄激素受体（AR）信号之间存在双向相互作用。雄激素剥夺疗法（ADT）可能通过破坏铁和脂质稳态，使癌细胞对铁死亡敏感；而铁死亡诱导的氧化应激又可能减弱AR的转录活性。研究还探讨了MBOAT2、SLC7A11和PEX10等AR调控的铁死亡抗性关键介质，并提出了将铁死亡诱导剂与AR靶向疗法联用，有望克服治疗抵抗，实现精准肿瘤学。这一发现为治疗去势抵抗性前列腺癌（CRPC）提供了新策略。科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。
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