欢迎收听科研喵的医学播客！使用AI读文献，效率百倍，就在labcat.com.cn。今天的热门话题是《国际分子医学杂志》上的最新研究：肿瘤病毒疗法的抗性机制与治疗突破。研究发现，肿瘤病毒疗法（OV）作为一种新兴的免疫治疗手段，能够通过直接杀死肿瘤细胞或诱导免疫原性细胞死亡来增强免疫反应。然而，临床试验中OV的疗效并不理想。本综述全面探讨了肿瘤和肿瘤细胞特性、基质细胞和细胞外基质（ECM）因素以及宿主免疫状态三个维度的抗性机制，并提出了潜在的解决方案。例如，通过预测OV疗效的生物标志物、利用ECM降解酶以及与免疫检查点抑制剂联合使用，有望提高OV的治疗效果。未来研究有望优化OV治疗，为癌症患者带来更好的免疫治疗结果。不要错过这一前沿进展，立即访问labcat.com.cn了解详情。
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