科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们要介绍一篇发表在《Trends in pharmacological sciences》(影响因子13.9)上的重要综述——《The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics》。这项研究揭示了B7-H3这一免疫检查点配体在癌症和肥胖中的双重作用，不仅是一种肿瘤相关抗原，还新发现它能调节肥胖。更令人兴奋的是，靶向B7-H3的抗体药物偶联物和CAR细胞疗法已在临床试验中展现出良好的安全性和有效性。这些突破性发现为癌症免疫治疗开辟了新途径，可能改变未来多种癌症的治疗格局。
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