科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们要介绍发表在《Trends in pharmacological sciences》(IF:13.9)上的重要综述"The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics"。这项研究揭示了B7-H3作为免疫检查点配体和肿瘤相关抗原的多重功能，不仅参与肿瘤微环境调控，还发现其与肥胖相关的新作用。更令人振奋的是，针对B7-H3的抗体药物偶联物和CAR细胞临床试验已在多种癌症中显示出安全性和有效性。此外，研究者还介绍了TOP CAR细胞、双特异性ADCs等创新疗法，为癌症免疫治疗开辟了新途径。这项研究为理解B7-H3的生物学功能和开发靶向疗法提供了重要见解。
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