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科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Trends in pharmacological sciences》(IF: 13.9)上的综述《The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics》。这项研究揭示了B7-H3作为免疫检查点配体和肿瘤相关抗原的多重功能，不仅参与二聚化、糖基化和细胞代谢调控，还发现其作为肥胖调节剂的新作用。临床试验证明，针对B7-H3的抗体药物偶联物和CAR免疫细胞在不同癌症中安全有效。研究还介绍了多种新型靶向疗法，包括TOP CAR细胞、双特异性ADCs和CAR-NK细胞，为癌症免疫治疗开辟了新途径。
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