科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。 今天我们要介绍的是发表在《Trends in molecular medicine》(影响因子12.8)上的重要论文《AAV vectors: an emerging strategy for chronic pain management.》。这项研究系统总结了腺相关病毒(AAV)载体作为慢性疼痛管理基因治疗工具的前沿进展。全球有数百万人受慢性疼痛困扰，已成为重要的公共健康问题。研究表明，AAV载体通过靶向神经元和非神经元细胞中的分子疼痛通路，能够提供精确且持久的疼痛缓解。研究团队概述了神经病理性、炎症性和癌症相关疼痛的临床前创新，并提供了骨关节炎患者中AAV疼痛调节的临床数据。同时，论文全面分析了AAV治疗的关键问题，包括潜在免疫反应、毒性和不良反应。这项研究为慢性疼痛治疗开辟了新方向，可能改变未来疼痛管理的方式。
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