科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Journal of the American Academy of Dermatology》(IF:12.8)上的重要研究"Impact of Immunosuppression on Cutaneous Squamous Cell Carcinoma Outcomes"。这项涉及11,930名患者的国际多中心研究发现，免疫抑制不仅是皮肤鳞状细胞癌的危险因素，更是独立预测不良预后的关键指标。免疫抑制患者表现出更高风险肿瘤特征和更差疾病结局，包括局部复发、远处转移和疾病特异性死亡。研究特别指出，器官移植和慢性淋巴细胞白血病患者面临不同风险模式。这一发现为临床风险评估提供了重要依据，建议将免疫抑制状态纳入皮肤鳞状细胞癌的风险预测模型，以指导个体化治疗和随访策略。
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