科研喵使用ai读文献,祝你效率百倍,访问labcat.com.cn下载。本期关注发表在《Trends in molecular medicine》(IF:12.8)上的重要论文《Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma》。这项研究揭示了致癌基因MYCN如何通过重编程肿瘤代谢,创造复杂的细胞间代谢回路,导致神经母细胞瘤免疫抑制微环境的形成。研究还发现,这些代谢过程受昼夜节律和宿主饮食的调节。论文提供了重要证据,表明针对MYCN重编程代谢的治疗策略有望改善患者预后,为神经母细胞瘤这一难治性癌症提供了新的治疗思路。
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