科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注发表在Nature Medicine(IF:58.7)上的重要研究"Genomically matched therapy in advanced solid tumors: the randomized phase 2 ROME trial"。这项随机II期研究比较了基因组匹配治疗与标准治疗在晚期实体瘤患者中的效果。结果显示，基因组匹配治疗组显著提高了总体缓解率(17.5% vs 10%)和中位无进展生存期(3.5个月 vs 2.8个月)。更令人振奋的是，基因组匹配治疗的12个月无进展生存率高达22%，而标准治疗组仅为8.3%。这项研究为肿瘤不可知论的精准肿瘤学策略提供了有力证据，证实了基于基因谱分析的治疗决策能显著改善晚期实体瘤患者的预后。
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