科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。 今天我们关注一篇发表在《Trends in pharmacological sciences》(影响因子13.9)上的重要研究，题为"Reprogramming SUMO-primed ubiquitylation: opportunities in oncology and neurology"。这项研究探讨了小泛素相关修饰(SUMO)靶向泛素连接酶(StUbLs)在疾病治疗中的潜力。研究人员发现，像三氧化二砷和氟维司群这样的抗癌药物能够利用SUMO化-泛素级联反应来失活致癌蛋白PML-RARα和雌激素受体α。更令人兴奋的是，新型 proximity-inducing 技术可将聚集蛋白招募到StUbL系统中，有望减轻神经毒性包涵物的形成。这一突破为肿瘤学和神经疾病领域开辟了全新的治疗途径，通过重新编程SUMO-StUbL信号通路，我们可能开发出针对更广泛疾病相关蛋白的靶向疗法。
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