科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Journal of nanobiotechnology(影响因子10.6)上的重要论文"Lipid-based nanoparticles external triggered release strategies in cancer nanomedicine"。研究指出，近半数人一生中将患癌症，而传统化疗药物面临递送挑战——不到0.1%的药物能到达肿瘤部位。脂质基纳米颗粒(LBNPs)虽能延长药物循环时间并利用EPR效应，但过于稳定的特性限制了药效释放。本文综述了热、超声、辐射、磁和光等外部触发策略的最新进展，这些技术可实现肿瘤部位的精准药物释放，大幅提高治疗效果并减少副作用，为癌症纳米医学开辟了新路径。
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