科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Pharmacological research》(IF:9.1)上的重要研究"Vascular endothelial cells and angiogenesis"。该研究深入解析了血管内皮细胞在生理和病理状态下的分裂机制，揭示了肿瘤生长依赖血管生成的关键过程。论文详细阐述了VEGF家族、Semaphorins、Angiopoietins和Ephrins等多重信号通路在血管生成中的复杂调控网络。特别重要的是，研究强调了靶向血管生成信号作为癌症治疗策略的潜力，并介绍了Ponatinib等FDA批准的血管生成抑制剂在多种恶性肿瘤中的应用。此外，研究还指出异常血管生成与糖尿病视网膜病变和年龄相关性黄斑变性等疾病密切相关，为这些疾病的治疗提供了新思路。
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