科研喵使用ai读文献,祝你效率百倍,访问labcat.com.cn下载。本期关注发表在Journal of nanobiotechnology(影响因子10.6)上的重要研究:"Programmable metal-based immuno-photocatalytic nanoparticles for precision activation of anti-tumor immunity"。这项突破性研究开发了一种新型纳米平台,通过整合光疗与免疫调节,时空特异性地激活抗肿瘤免疫。这些智能纳米颗粒能产生活性氧,刺激免疫原性细胞死亡,同时递送免疫检查点抑制剂和佐剂,重塑肿瘤微环境。临床前模型显示它们显著抑制肿瘤生长,激活免疫系统并预防转移,且全身毒性极低。这项技术为治疗免疫抵抗性肿瘤提供了全新思路,有望实现精准、微创的个性化癌症免疫治疗,代表了纳米医学在肿瘤治疗领域的重大进展。
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