科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《International journal of molecular medicine》(影响因子5.7)上的重要综述"Cholesterol metabolism and cancer: Molecular mechanisms, immune regulation and an epidemiological perspective"。这项研究揭示了胆固醇代谢与癌症之间的复杂联系，发现癌细胞通过重塑胆固醇稳态促进肿瘤侵袭和转移。胆固醇在肿瘤免疫微环境中展现双重角色：既增强T细胞抗肿瘤功能，其氧化衍生物又导致T细胞耗竭。研究指出，靶向胆固醇代谢可能是触发铁死亡、逆转耐药性和重新激活抗肿瘤免疫的新策略，为癌症治疗提供了全新视角。
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