科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。 本期关注发表在《Cell》(影响因子45.5)上的重要研究："CRATER tumor niches facilitate CD8(+) T cell engagement and correspond with immunotherapy success"。这项研究通过斑马鱼模型和人类黑色素瘤的多重成像，发现了CRATERs这一特殊结构——位于基质-黑素细胞边界的"免疫热点区域"。这些区域富含抗原识别分子，聚集了肿瘤中最高密度的CD8(+) T细胞，形成活跃的肿瘤杀灭环境。研究团队发现，免疫治疗后CRATERs显著扩展，成为T细胞发挥作用的主要战场。更令人兴奋的是，人类患者中CRATERs密度升高与免疫治疗临床反应直接相关。这一发现为预测免疫治疗效果提供了新的生物标志物，为个性化癌症免疫治疗开辟了新途径。
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