科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《International journal of molecular sciences》(IF: 4.9)上的研究"HPV-Independent Cervical Cancer-A New Challenge of Modern Oncology"。这项重要研究揭示了约5-11%的宫颈癌病例与HPV无关，具有独特的分子特征和临床行为。这些肿瘤表现出TP53、PIK3CA等特定突变，诊断常被延误，导致高级别表现阶段和对治疗反应降低。研究发现，PI3K/mTOR和KRAS抑制剂可能为这些患者提供新的治疗选择，强调了精准医疗在这种侵袭性宫颈癌中的必要性。这一发现对宫颈癌的精准诊断和治疗策略具有重要意义。
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