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帝曰，人年老而無子者，材力盡邪？將天數然也？歧伯曰，女子七歲，腎氣盛，齒更發長。二七而天癸至，任脈通，太沖脈盛，月事以時下，故有子。三七腎氣平均，故眞牙生而長極。四七筋骨堅，發長極，身體盛壯。五七陽明脈衰，面始焦，發始墮。六七三陽脈衰於上，面皆焦，發始白。七七任脈虛，太沖脈衰少，天癸竭，地道不通，故形壞而無子也。
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