Aaron Boster

And it's such an impactful thing in my life.

I want to give a shout out to my patients in central Ohio who participated in that trial.

And it's because of that that we can prove that this drug works in these different phenotypes for MS.

That's a really special thing to me.

yeah winter environment there's a really really good reason so you know i'm holding up this wire right and let's take an analogy of like a extension cord that you'd use for your christmas lights okay so you have the extension cord out and your spouse runs over with a lawnmower doesn't cut it in half but nicks it and your spouse does what they're supposed to do they don't tell anyone they just duct tape it up and they put it away right why didn't you tell me

So then the wire no longer works 100%.

It works, say, 90%.

Now, later when you get the extension cord out and you plug in two Christmas lights, they're gorgeous.

They're sparkly.

You just love them.

And then you put in five more or 10 more lights and the whole thing short circuits because that damaged wire cannot hold a full load, right?

And so this is actually what's happening with the central nervous system.

And that wire could be your spinal cord.

It's a pretty good analogy.

So

When there's been damage to the spinal cord and you strip the myelin, that's the plastic coating on the wire, off, you have what's called a conduction block where the electricity just doesn't go through.

And then what your body does is it puts in a bunch of ion channels.

And so you can conduct electricity.

And let me use an analogy, the Great Wall of China.

So the way that they communicated on the Great Wall of China was every couple of miles, they'd have a bonfire.