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Aaron Boster

👤 Person
887 total appearances

Appearances Over Time

Podcast Appearances

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Remyelination is when you would put it back on.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And I hypothesize that there's three kinds of therapies that we need to cure MS.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

The first is a remyelinating agent, and we don't have one yet.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

We've been working on it.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

We have failed multiple times in trying to develop a remyelinating agent.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

We've had some close ones where we were really excited and then fell on our noses.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Yeah.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

So anti-lingo.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

Yep.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And it didn't work out.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

The second thing that we need is a neuroprotective agent.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And unfortunately, we really don't have that yet.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

The third thing that we need and we have in spades is specific anti-inflammatories.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And I don't mean anti-inflammatory like an aspirin.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

I mean central nervous system anti-inflammatories, like you mentioned, B-cell depleters like Ocrevus, Ocrelizumab.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

So this is a huge area of interest in MS research and in specific in like MS therapeutics.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

We're not really working so much anymore on like the next anti-inflammatory because we have those.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

A lot of the efforts are instead being placed on some of these other areas, which is appropriate and really, really exciting.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

This is a very important topic.

Ologies with Alie Ward
Neuropathoimmunology (MULTIPLE SCLEROSIS) with Aaron Boster

And so what you're talking about is a stem cell transplant.