Menu
Sign In Search Podcasts Libraries Charts People & Topics Add Podcast API Blog Pricing

Adolfo Garcia-Sastre

๐Ÿ‘ค Speaker
98 total appearances

Appearances Over Time

Podcast Appearances

Short Wave
How a single flu shot could protect you for decades

Now we have some candidates.

Short Wave
How a single flu shot could protect you for decades

Yeah, correct.

Short Wave
How a single flu shot could protect you for decades

So phase one, the main thing that tells you is safety.

Short Wave
How a single flu shot could protect you for decades

And the second thing I tell you, whether you get the immune response that you think is good for the vaccine.

Short Wave
How a single flu shot could protect you for decades

In phase one, we got induction of antibodies at levels that we think they will be protective.

Short Wave
How a single flu shot could protect you for decades

We have not been able to prove that in humans, but we think that the levels that we achieve, they will be protective.

Short Wave
How a single flu shot could protect you for decades

Phase two, we have not started.

Short Wave
How a single flu shot could protect you for decades

We have been in phase one.

Short Wave
How a single flu shot could protect you for decades

Money, mainly money.

Short Wave
How a single flu shot could protect you for decades

They are very costly.

Short Wave
How a single flu shot could protect you for decades

And there was a NIH program that was called Civic that was for trying to get improved influenza vaccines.

Short Wave
How a single flu shot could protect you for decades

We were part of this program, but this program has been stopped.

Short Wave
How a single flu shot could protect you for decades

And right now it's unclear whether it's going to restart.

Short Wave
How a single flu shot could protect you for decades

Well, it was not really a cut, but there has been also a lot of slowdown in finances from NIH.

Short Wave
How a single flu shot could protect you for decades

So these contracts, they were supposed to, at one moment, bring clinical trials.

Short Wave
How a single flu shot could protect you for decades

But because funding stopped it and there is no call for new proposals yet, and if a call comes...

Short Wave
How a single flu shot could protect you for decades

because it takes time to review and then get funded, there's going to be at least a gap of one year or two years.

Short Wave
How a single flu shot could protect you for decades

The problem with the vaccines that we are ready to go is that if they are not going, they need to maintain a stability program, and this costs money, money that we don't have.

Short Wave
How a single flu shot could protect you for decades

So we are trying to find partners

Short Wave
How a single flu shot could protect you for decades

outside NIH to finance for at least a stability program, or if not, also for some phase two, phase one clinical trials that we still need to do.