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Anna Greka

👤 Person
316 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And that sort of led us into, you know, the early projects in my young lab.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And in fact, it's interesting, we didn't talk about that work, but that work in itself actually has made it all the way to phase two trials in patients.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

This was a paper we published in Science in 2017.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And in follow on to that work, there was an opportunity to build this into a real drug, targeting one of these ion channels that has made it into phase two trials.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And we'll see what happens next.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

But it's this idea of sort of

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

following your scientific curiosity, which I also talked about in my TED talk, because you don't know to what wonderful places it will lead you.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And quite interestingly, now my lab is back into studying familial Alzheimer's and retinitis pigmentosa in the eye and the brain.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

So I tell people,

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

do not, you know, you know, limit yourself to whatever, you know, someone says your field is or should be, you know, just follow your scientific curiosity.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And usually that takes you a lot more interesting places.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And so that's certainly been a theme for my career, I would say.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Sure.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Yeah, thank you.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

I think there are many ways in which, you know, even for quite a long time before AI became such a, you know, well known kind of household term, if you will, the concept of machine learning in terms of image processing is something that has been around for some time.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And so this is actually a form of AI that we use in order to kind of process millions of images.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

My lab has by now produced probably more than 20 million images over the last few years, maybe five to six years.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And so if you can imagine, it's impossible for any human to process this many images and make sense of them.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

So of course we've been using machine learning

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

that is becoming increasingly more and more sophisticated and advanced in terms of being able to do analysis of images, which is a lot of what we cell biologists do, of course.