Menu
Sign In Search Podcasts Charts People & Topics Add Podcast API Pricing

Betül Kaçar

👤 Speaker
1202 total appearances

Appearances Over Time

Podcast Appearances

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

But the point is that you will still end up with the same amino acids or something similar to it, even if you mess up the code.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

Which errors result in the same output, like the same function and which don't, which actually results in a dysfunction or which are... We understand to some degree how translation and the rest of the cell work together, how an error at the translation level, this is the really core level, can impact entire cell.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

But we understand very little about the evolutionary mechanisms behind the selection of the system.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

It's thought to be one of the hardest problems in biology, and it is still the dark side of biology, even though it is so essential.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

So this is, yeah, you're looking at the...

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

language of life, so to speak, and how it can found ways rather to tolerate its own mistakes.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

Because all the final letters, that's the 20 amino acids, that's our alphabet.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

They are all brought together with these bits of information, right?

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

So when you look at the genes, you're looking at those four letters.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

When you look at the proteins, you're looking at the 20 amino acids, which may be a little easier way to track the information when we create the tree.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

It's one perspective.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

We are not that good at it yet, right?

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

If you're a biologist and you want to understand how life evolved from a molecular perspective, this would be the way to do it.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

And this is what nature narrowed its code down to.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

So when we think of nitrogen, when we think of carbon, when we think of sulfur, it's all in this, that all these nucleotides are built based on those elements.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

Exactly.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

That's the informatic perspective.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

And it's important to emphasize that this is not engineered by humans.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

This evolved by itself.

Lex Fridman Podcast
#350 – Betül Kaçar: Origin of Life, Ancient DNA, Panspermia, and Aliens

It appears to be a highly optimized chemical and information code.