Charan Ranganath

Blood sugar also seems to be related to these issues. And diabetes is like so bad in so many ways. It's associated with those white matter hyperintensities that we talked about. And so that's bad. We've done some research on that. But it also affects – it can cause little – if you get severe diabetic ketoacidosis, you can actually have hippocampal damage from that directly.

Blood sugar also seems to be related to these issues. And diabetes is like so bad in so many ways. It's associated with those white matter hyperintensities that we talked about. And so that's bad. We've done some research on that. But it also affects – it can cause little – if you get severe diabetic ketoacidosis, you can actually have hippocampal damage from that directly.

And it also dramatically increases Alzheimer's risk. We have an epidemic of diabetes right now.

And it also dramatically increases Alzheimer's risk. We have an epidemic of diabetes right now.

And it also dramatically increases Alzheimer's risk. We have an epidemic of diabetes right now.

There are now some drugs that are, I think they're targeting amyloid that are producing some modest effects in stalling the progression of the disease. See, the problem with Alzheimer's, as you know, is once you lose neurons, you're not getting them back, right? And it's like, yeah, there's neurogenesis and you can run around, but it's not much. If you're depending on that, you're hosed.

There are now some drugs that are, I think they're targeting amyloid that are producing some modest effects in stalling the progression of the disease. See, the problem with Alzheimer's, as you know, is once you lose neurons, you're not getting them back, right? And it's like, yeah, there's neurogenesis and you can run around, but it's not much. If you're depending on that, you're hosed.

There are now some drugs that are, I think they're targeting amyloid that are producing some modest effects in stalling the progression of the disease. See, the problem with Alzheimer's, as you know, is once you lose neurons, you're not getting them back, right? And it's like, yeah, there's neurogenesis and you can run around, but it's not much. If you're depending on that, you're hosed.

But getting back to the exercise thing, It's neuroprotective. And so like let's say with a drug, right? I mean everybody wants a drug. If I told you I give you this drug, you're 60 years old, and it's going to have some terrible side effects. You're going to get diarrhea, nausea, all this stuff. But it will reduce your risk of Alzheimer's by 40%. A lot of people would be motivated to take it.

But getting back to the exercise thing, It's neuroprotective. And so like let's say with a drug, right? I mean everybody wants a drug. If I told you I give you this drug, you're 60 years old, and it's going to have some terrible side effects. You're going to get diarrhea, nausea, all this stuff. But it will reduce your risk of Alzheimer's by 40%. A lot of people would be motivated to take it.

But getting back to the exercise thing, It's neuroprotective. And so like let's say with a drug, right? I mean everybody wants a drug. If I told you I give you this drug, you're 60 years old, and it's going to have some terrible side effects. You're going to get diarrhea, nausea, all this stuff. But it will reduce your risk of Alzheimer's by 40%. A lot of people would be motivated to take it.

Now I tell you, okay, well, here's a lifestyle intervention that's going to involve what Sarah Madden calls downstates. We can actually get into that and memory reactivation during downstates, but involves sleep, diet, exercise, social stimulation, right? And these things, by the way, also reinforce each other. Right. Having better sleep makes it easier to exercise.

Now I tell you, okay, well, here's a lifestyle intervention that's going to involve what Sarah Madden calls downstates. We can actually get into that and memory reactivation during downstates, but involves sleep, diet, exercise, social stimulation, right? And these things, by the way, also reinforce each other. Right. Having better sleep makes it easier to exercise.

Now I tell you, okay, well, here's a lifestyle intervention that's going to involve what Sarah Madden calls downstates. We can actually get into that and memory reactivation during downstates, but involves sleep, diet, exercise, social stimulation, right? And these things, by the way, also reinforce each other. Right. Having better sleep makes it easier to exercise.

Having exercise makes it better to sleep. All of these improve mood, right? So these will improve your mental function, your mood, as well as your mental function relatively soon and reduce your risk by at least 40%, if not more. Wow.

Having exercise makes it better to sleep. All of these improve mood, right? So these will improve your mental function, your mood, as well as your mental function relatively soon and reduce your risk by at least 40%, if not more. Wow.

Having exercise makes it better to sleep. All of these improve mood, right? So these will improve your mental function, your mood, as well as your mental function relatively soon and reduce your risk by at least 40%, if not more. Wow.

If you go to – I can send you this Lancet article, but it's like the amount – the proportion of variance, meaning the degree of risk that you can reduce with fully preventable or fully in our control lifestyle issues is huge. It's as big or bigger than the genetics.

If you go to – I can send you this Lancet article, but it's like the amount – the proportion of variance, meaning the degree of risk that you can reduce with fully preventable or fully in our control lifestyle issues is huge. It's as big or bigger than the genetics.

If you go to – I can send you this Lancet article, but it's like the amount – the proportion of variance, meaning the degree of risk that you can reduce with fully preventable or fully in our control lifestyle issues is huge. It's as big or bigger than the genetics.