Charan Ranganath
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Podcast Appearances
I mean this is a health thing that can really affect people and it can โ I don't think anybody โ it's not a political issue to get brain fog. It just sucks, right? Nobody wants this. So I think that there's a lot we're learning about viruses and bacteria. One of the cool things I was talking about before we started recording is I was at a conference.
I met the coolest guy, and I'm blanking on his name, but I'll send it to you after. But he did this great study, and he was studying the effects of nutrition on brain health and memory, especially cognition. So I said, what's the most interesting finding that you've gotten? I love to ask people this because I'm curious and it stimulates my curiosity and I usually get a good answer.
I met the coolest guy, and I'm blanking on his name, but I'll send it to you after. But he did this great study, and he was studying the effects of nutrition on brain health and memory, especially cognition. So I said, what's the most interesting finding that you've gotten? I love to ask people this because I'm curious and it stimulates my curiosity and I usually get a good answer.
I met the coolest guy, and I'm blanking on his name, but I'll send it to you after. But he did this great study, and he was studying the effects of nutrition on brain health and memory, especially cognition. So I said, what's the most interesting finding that you've gotten? I love to ask people this because I'm curious and it stimulates my curiosity and I usually get a good answer.
So he told me he did this study where he has these rats and he gives them sugary water during the day about the equivalent, he said, to a can of Coke a day. So they're getting this sugar. When they reach adulthood, you know, these teenage rats, they reach adulthood and they have memory problems and they have hippocampal atrophy.
So he told me he did this study where he has these rats and he gives them sugary water during the day about the equivalent, he said, to a can of Coke a day. So they're getting this sugar. When they reach adulthood, you know, these teenage rats, they reach adulthood and they have memory problems and they have hippocampal atrophy.
So he told me he did this study where he has these rats and he gives them sugary water during the day about the equivalent, he said, to a can of Coke a day. So they're getting this sugar. When they reach adulthood, you know, these teenage rats, they reach adulthood and they have memory problems and they have hippocampal atrophy.
So you go, okay, well, the hippocampus is affected, memory is affected, sugar, blah, blah, blah, no problem. So then what he does is he takes the gut bacteria from the sugar animals and puts it in an animal that doesn't get this diet. And he finds the same kind of pathology and the same kind of memory deficit in these animals.
So you go, okay, well, the hippocampus is affected, memory is affected, sugar, blah, blah, blah, no problem. So then what he does is he takes the gut bacteria from the sugar animals and puts it in an animal that doesn't get this diet. And he finds the same kind of pathology and the same kind of memory deficit in these animals.
So you go, okay, well, the hippocampus is affected, memory is affected, sugar, blah, blah, blah, no problem. So then what he does is he takes the gut bacteria from the sugar animals and puts it in an animal that doesn't get this diet. And he finds the same kind of pathology and the same kind of memory deficit in these animals.
So there's something about that process of like the gut-brain interaction that also seems to be playing a part in ways that I don't understand. I think they're still figuring it out. But again, this really shows this tight neuroimmune link. We're seeing this now with pollution. Air pollution is a big factor.
So there's something about that process of like the gut-brain interaction that also seems to be playing a part in ways that I don't understand. I think they're still figuring it out. But again, this really shows this tight neuroimmune link. We're seeing this now with pollution. Air pollution is a big factor.
So there's something about that process of like the gut-brain interaction that also seems to be playing a part in ways that I don't understand. I think they're still figuring it out. But again, this really shows this tight neuroimmune link. We're seeing this now with pollution. Air pollution is a big factor.
So even if people don't believe in global warming, there's nothing good about being in a place with a lot of smoke in the air, you know. It definitely can and this is one of the risk factors that is noted in the Lancet report for Alzheimer's disease.
So even if people don't believe in global warming, there's nothing good about being in a place with a lot of smoke in the air, you know. It definitely can and this is one of the risk factors that is noted in the Lancet report for Alzheimer's disease.
So even if people don't believe in global warming, there's nothing good about being in a place with a lot of smoke in the air, you know. It definitely can and this is one of the risk factors that is noted in the Lancet report for Alzheimer's disease.
One of my colleagues Pam Line is doing research on this at UC Davis showing that you get like she actually takes real pollution from the Caldecott tunnel which connects Oakland and Walnut Creek and finds that rats exposed to this pollution. damage. So there's so many of these environmental factors that can trigger the inflammatory response. We talked about blood sugar.
One of my colleagues Pam Line is doing research on this at UC Davis showing that you get like she actually takes real pollution from the Caldecott tunnel which connects Oakland and Walnut Creek and finds that rats exposed to this pollution. damage. So there's so many of these environmental factors that can trigger the inflammatory response. We talked about blood sugar.
One of my colleagues Pam Line is doing research on this at UC Davis showing that you get like she actually takes real pollution from the Caldecott tunnel which connects Oakland and Walnut Creek and finds that rats exposed to this pollution. damage. So there's so many of these environmental factors that can trigger the inflammatory response. We talked about blood sugar.
Blood sugar also seems to be related to these issues. And diabetes is like so bad in so many ways. It's associated with those white matter hyperintensities that we talked about. And so that's bad. We've done some research on that. But it also affects โ it can cause little โ if you get severe diabetic ketoacidosis, you can actually have hippocampal damage from that directly.