Charan Ranganath

Gum disease, it turns out, increases your risk for, I believe it's Alzheimer's and also for cognitive brain health in general.

Gum disease, it turns out, increases your risk for, I believe it's Alzheimer's and also for cognitive brain health in general.

Gum disease, it turns out, increases your risk for, I believe it's Alzheimer's and also for cognitive brain health in general.

Yeah, yeah. I mean, I don't know the detailed mechanisms, but I think that makes sense. And there's this vague notion of cognitive reserve, which is basically some people seem to be quite immune to the effects of cognitive aging, and some people seem to be very protected against Alzheimer's disease. So what is it?

Yeah, yeah. I mean, I don't know the detailed mechanisms, but I think that makes sense. And there's this vague notion of cognitive reserve, which is basically some people seem to be quite immune to the effects of cognitive aging, and some people seem to be very protected against Alzheimer's disease. So what is it?

Yeah, yeah. I mean, I don't know the detailed mechanisms, but I think that makes sense. And there's this vague notion of cognitive reserve, which is basically some people seem to be quite immune to the effects of cognitive aging, and some people seem to be very protected against Alzheimer's disease. So what is it?

One of the things that seems to come up as far as depleting cognitive reserve or putting it at a higher risk seems to be inflammation, right, neuroinflammation. And so Kim McAllister, as you know, is doing work on this topic of neuroimmune interactions. Mm-hmm. Basically, the immune system expresses itself in the brain. You get microglia activation that can cause these inflammatory responses.

One of the things that seems to come up as far as depleting cognitive reserve or putting it at a higher risk seems to be inflammation, right, neuroinflammation. And so Kim McAllister, as you know, is doing work on this topic of neuroimmune interactions. Mm-hmm. Basically, the immune system expresses itself in the brain. You get microglia activation that can cause these inflammatory responses.

One of the things that seems to come up as far as depleting cognitive reserve or putting it at a higher risk seems to be inflammation, right, neuroinflammation. And so Kim McAllister, as you know, is doing work on this topic of neuroimmune interactions. Mm-hmm. Basically, the immune system expresses itself in the brain. You get microglia activation that can cause these inflammatory responses.

And there's reasonable evidence suggests that it's interacting with tau and amyloid and this kind of cascade of stuff that happens in Alzheimer's disease, right? And one of the things that we're learning now, and we don't know nearly enough, but the data out there is quite scary, in fact, is long COVID is associated with significant cognitive effects.

And there's reasonable evidence suggests that it's interacting with tau and amyloid and this kind of cascade of stuff that happens in Alzheimer's disease, right? And one of the things that we're learning now, and we don't know nearly enough, but the data out there is quite scary, in fact, is long COVID is associated with significant cognitive effects.

And there's reasonable evidence suggests that it's interacting with tau and amyloid and this kind of cascade of stuff that happens in Alzheimer's disease, right? And one of the things that we're learning now, and we don't know nearly enough, but the data out there is quite scary, in fact, is long COVID is associated with significant cognitive effects.

Well, so they report a subjective brain fog and you can see this, you can measure this as a significant cognitive deficit that they're experiencing, right? And we've seen in the past like HIV was, there was actually a whole variety of dementia that was associated with HIV from the viral transmission.

Well, so they report a subjective brain fog and you can see this, you can measure this as a significant cognitive deficit that they're experiencing, right? And we've seen in the past like HIV was, there was actually a whole variety of dementia that was associated with HIV from the viral transmission.

Well, so they report a subjective brain fog and you can see this, you can measure this as a significant cognitive deficit that they're experiencing, right? And we've seen in the past like HIV was, there was actually a whole variety of dementia that was associated with HIV from the viral transmission.

We can – like you can see with multiple sclerosis where you have like autoimmune responses in the brain affect mental function dramatically. We're seeing more and more evidence of this. So this is again another one of those things. It's like people go, oh, COVID. I don't care about it, blah, blah, blah.

We can – like you can see with multiple sclerosis where you have like autoimmune responses in the brain affect mental function dramatically. We're seeing more and more evidence of this. So this is again another one of those things. It's like people go, oh, COVID. I don't care about it, blah, blah, blah.

We can – like you can see with multiple sclerosis where you have like autoimmune responses in the brain affect mental function dramatically. We're seeing more and more evidence of this. So this is again another one of those things. It's like people go, oh, COVID. I don't care about it, blah, blah, blah.

I mean this is a health thing that can really affect people and it can – I don't think anybody – it's not a political issue to get brain fog. It just sucks, right? Nobody wants this. So I think that there's a lot we're learning about viruses and bacteria. One of the cool things I was talking about before we started recording is I was at a conference.

I mean this is a health thing that can really affect people and it can – I don't think anybody – it's not a political issue to get brain fog. It just sucks, right? Nobody wants this. So I think that there's a lot we're learning about viruses and bacteria. One of the cool things I was talking about before we started recording is I was at a conference.