Charles Piller
π€ SpeakerAppearances Over Time
Podcast Appearances
that merits a lot of attention and can have some success. So all of these things are happening simultaneously. But when you have one idea that has so deeply captured a lot of the scientific thinking in the field, it can crowd out things. I like to think of it a little bit as, you know, if you want to use an analogy to why do farmers rotate crops?
Because if you have a monoculture, one crop in the same field for year after year after year after year, It can exhaust the soil of nutrients that it needs. And so they rotate crops. I think there needs to be some rotation of ideas within Alzheimer's more than we see today in order to come to the full potential of innovation.
Because if you have a monoculture, one crop in the same field for year after year after year after year, It can exhaust the soil of nutrients that it needs. And so they rotate crops. I think there needs to be some rotation of ideas within Alzheimer's more than we see today in order to come to the full potential of innovation.
Because if you have a monoculture, one crop in the same field for year after year after year after year, It can exhaust the soil of nutrients that it needs. And so they rotate crops. I think there needs to be some rotation of ideas within Alzheimer's more than we see today in order to come to the full potential of innovation.
And within this research that you've investigated so thoroughly, has there been evidence that was supporting the amyloid model that has been disproven or has it largely stayed out of that discussion?
And within this research that you've investigated so thoroughly, has there been evidence that was supporting the amyloid model that has been disproven or has it largely stayed out of that discussion?
And within this research that you've investigated so thoroughly, has there been evidence that was supporting the amyloid model that has been disproven or has it largely stayed out of that discussion?
Well, the genesis of my interest in this had to do with a famous experiment, one of the most influential experiments in Alzheimer's disease, basic science experiments. And this was done by scientists primarily at the University of Minnesota. And what this experiment did is that they extracted a certain type of
Well, the genesis of my interest in this had to do with a famous experiment, one of the most influential experiments in Alzheimer's disease, basic science experiments. And this was done by scientists primarily at the University of Minnesota. And what this experiment did is that they extracted a certain type of
Well, the genesis of my interest in this had to do with a famous experiment, one of the most influential experiments in Alzheimer's disease, basic science experiments. And this was done by scientists primarily at the University of Minnesota. And what this experiment did is that they extracted a certain type of
amyloid protein from genetically engineered mice that were designed to produce a lot of amyloid protein in their brains. They extracted this protein, a certain specific type of amyloid protein that they called amyloid beta star 56. They even came up with that kind of clever name for it, AB star 56, that was very memorable.
amyloid protein from genetically engineered mice that were designed to produce a lot of amyloid protein in their brains. They extracted this protein, a certain specific type of amyloid protein that they called amyloid beta star 56. They even came up with that kind of clever name for it, AB star 56, that was very memorable.
amyloid protein from genetically engineered mice that were designed to produce a lot of amyloid protein in their brains. They extracted this protein, a certain specific type of amyloid protein that they called amyloid beta star 56. They even came up with that kind of clever name for it, AB star 56, that was very memorable.
And then they injected it into rats and the rats then showed signs of memory loss that could be compared to certain symptoms of Alzheimer's disease. So what was really interesting about this experiment was that it was a sort of proof of concept that amyloid proteins had a direct relationship to causing something like Alzheimer's, at least in rats. And so,
And then they injected it into rats and the rats then showed signs of memory loss that could be compared to certain symptoms of Alzheimer's disease. So what was really interesting about this experiment was that it was a sort of proof of concept that amyloid proteins had a direct relationship to causing something like Alzheimer's, at least in rats. And so,
And then they injected it into rats and the rats then showed signs of memory loss that could be compared to certain symptoms of Alzheimer's disease. So what was really interesting about this experiment was that it was a sort of proof of concept that amyloid proteins had a direct relationship to causing something like Alzheimer's, at least in rats. And so,
So, the initial article I did in this realm involved an assessment of that experiment and related work and what was found by a particular scientist with whom I worked very closely and who produced a dossier, you might call it,
So, the initial article I did in this realm involved an assessment of that experiment and related work and what was found by a particular scientist with whom I worked very closely and who produced a dossier, you might call it,
So, the initial article I did in this realm involved an assessment of that experiment and related work and what was found by a particular scientist with whom I worked very closely and who produced a dossier, you might call it,
on a lot of the experiments in this group was that this experiment was based on thoroughly doctored images, images that had been changed in ways so as to support the experimental premise and results. And so what you have here is a fundamental experiment in Alzheimer's disease that had a lot of influence in pushing the field forward and validating the amyloid hypothesis and encouraging people