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Charles Piller

πŸ‘€ Speaker
1670 total appearances

Appearances Over Time

Podcast Appearances

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

on a lot of the experiments in this group was that this experiment was based on thoroughly doctored images, images that had been changed in ways so as to support the experimental premise and results. And so what you have here is a fundamental experiment in Alzheimer's disease that had a lot of influence in pushing the field forward and validating the amyloid hypothesis and encouraging people

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

on a lot of the experiments in this group was that this experiment was based on thoroughly doctored images, images that had been changed in ways so as to support the experimental premise and results. And so what you have here is a fundamental experiment in Alzheimer's disease that had a lot of influence in pushing the field forward and validating the amyloid hypothesis and encouraging people

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

to look at new elements and permutations of that hypothesis in a way that had tremendous, tremendous force in the field. What we found was that it was based on false data, on data that was proved to be false. And two years after my story in science came out describing this, the paper was finally retracted by most of its authors.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

to look at new elements and permutations of that hypothesis in a way that had tremendous, tremendous force in the field. What we found was that it was based on false data, on data that was proved to be false. And two years after my story in science came out describing this, the paper was finally retracted by most of its authors.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

to look at new elements and permutations of that hypothesis in a way that had tremendous, tremendous force in the field. What we found was that it was based on false data, on data that was proved to be false. And two years after my story in science came out describing this, the paper was finally retracted by most of its authors.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

And it was appearing in the journal Nature, which is a very important, famous journal. So this was a kind of a landmark moment in a way. So to answer your question more broadly, in my book, Doctored, I... looked at several dozen important scientists in Alzheimer's research and, of course, their collaborators and their trainees.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

And it was appearing in the journal Nature, which is a very important, famous journal. So this was a kind of a landmark moment in a way. So to answer your question more broadly, in my book, Doctored, I... looked at several dozen important scientists in Alzheimer's research and, of course, their collaborators and their trainees.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

And it was appearing in the journal Nature, which is a very important, famous journal. So this was a kind of a landmark moment in a way. So to answer your question more broadly, in my book, Doctored, I... looked at several dozen important scientists in Alzheimer's research and, of course, their collaborators and their trainees.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

So all in all, representing the work of hundreds of scientists in the field, including some very important scientists. And so thousands of images in these many hundreds of papers that were examined were found to have been based on improperly changed or doctored image manipulation. What percentage of those were related to the amyloid hypothesis? The vast majority. And the reason is pretty clear.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

So all in all, representing the work of hundreds of scientists in the field, including some very important scientists. And so thousands of images in these many hundreds of papers that were examined were found to have been based on improperly changed or doctored image manipulation. What percentage of those were related to the amyloid hypothesis? The vast majority. And the reason is pretty clear.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

So all in all, representing the work of hundreds of scientists in the field, including some very important scientists. And so thousands of images in these many hundreds of papers that were examined were found to have been based on improperly changed or doctored image manipulation. What percentage of those were related to the amyloid hypothesis? The vast majority. And the reason is pretty clear.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

When the dominance of an idea is so extreme in an industry that most of the research is associated with, in one way or another, with the amyloid hypothesis, it's logical to understand that this would be found not just in good science, in strongly developed and reliable science, but also in doctor science or just plain poorly done experiments. And part of the reason for it is that

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

When the dominance of an idea is so extreme in an industry that most of the research is associated with, in one way or another, with the amyloid hypothesis, it's logical to understand that this would be found not just in good science, in strongly developed and reliable science, but also in doctor science or just plain poorly done experiments. And part of the reason for it is that

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

When the dominance of an idea is so extreme in an industry that most of the research is associated with, in one way or another, with the amyloid hypothesis, it's logical to understand that this would be found not just in good science, in strongly developed and reliable science, but also in doctor science or just plain poorly done experiments. And part of the reason for it is that

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

It's easier to get away with improperly changed, manipulated images in Alzheimer's disease if you're going for a set of ideas that is already well accepted in the field. There's less scrutiny. There are people who say, well, of course this is illogical.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

It's easier to get away with improperly changed, manipulated images in Alzheimer's disease if you're going for a set of ideas that is already well accepted in the field. There's less scrutiny. There are people who say, well, of course this is illogical.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

It's easier to get away with improperly changed, manipulated images in Alzheimer's disease if you're going for a set of ideas that is already well accepted in the field. There's less scrutiny. There are people who say, well, of course this is illogical.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

finding in this experiment because we know from this experiment and that experiment and these 50 other experiments that have done associated with the amyloid hypothesis that of course we're going to find something like this. And so people cut corners and they think, I'm never going to get caught on this.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

finding in this experiment because we know from this experiment and that experiment and these 50 other experiments that have done associated with the amyloid hypothesis that of course we're going to find something like this. And so people cut corners and they think, I'm never going to get caught on this.

The Checkup with Doctor Mike
Exposing Widespread Corruption In Alzheimer's Research | Charles Piller

finding in this experiment because we know from this experiment and that experiment and these 50 other experiments that have done associated with the amyloid hypothesis that of course we're going to find something like this. And so people cut corners and they think, I'm never going to get caught on this.