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Charlotte Bunne

👤 Person
104 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

And I'm affiliated to the hospitals to actually make this possible.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

And as a career advice, I think don't be shy and stick to your discipline.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

I think I have a bachelor's in biology, but I never only did biology.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

I have a PhD in computer science, which kind of you would think a bachelor in biology not necessarily qualifies you through.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So I think this interdisciplinarity also requires you to be very fluent, very comfortable in reading many different styles of papers and publications because of the course.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

publication in a computer science venue will be very, very different from the way we write in biology.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So don't stick to your study program, but just be free in selecting whatever course gets you closer to the knowledge you need in order to do the research or whatever task you're building and working on.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

Yes, so...

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So it depends, right?

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So I think if we look at certain spatial proteomics, we still have subcellular resolution.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So of course, we always measure many different cells, but we are able to somewhat get down to a resolution where we can look at certain co-localization of proteins.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

This also goes back to the point just made before, right?

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

Like having this very good environment to study like drugs, right?

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

Like if I want to build a new drug, if I want to build a new protein, the idea of building this multiscale model, right, allows us to actually...

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

simulate like different, like somehow binding changes and binding because we simulate the effect of a drug.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

Ultimately, the readers we have, they are subcellular.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

So, of course, we often, like in the spatial biology, we often have a bit like methods that are rather coarse.

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

They have a spot that averages over certain, like,

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

some cells right like hundreds of cells or few cells but i think we also have more and more technologies that are zooming in that are subcellular where we can actually tag or have like those probe-based methods that allow us to to zoom in there's microscopy of individual cells to really capture them in 3d they are of course not very throughput high throughput yet

Ground Truths
Steve Quake and Charlotte Bunne: The Holy Grail of Biology

but it gives us also an idea of the morphology and how ultimately morphology determines certain cellular properties or cellular phenotype.