David Allison

So the studies of caloric restriction in general

and protein restriction in particular, which show benefit, are much more present at 22 degrees Celsius, which for a mouse is a thermogenic challenge, thermoregulatory challenge, as opposed to thermoneutral conditions, roughly 27 to 30 degrees Celsius.

We don't live our own lives in the chronic cold.

So we'll leave that out there and say it depends on the conditions.

There's several threads you've allowed me to pick up here.

One has to do with the idea of categories.

All categories are social constructs.

We often hear that said about things like race, and it's true.

Race is a social construct.

So is furniture.

So is vaccine.

So is medicine, et cetera.

What you choose to use as a category and how you choose to define membership in that category is a judgment call.

And it's not intrinsically written in stone what that should be.

They're useful or not useful for your purposes.

That's the first thing to point out.

So same thing as ultra-processed.

There's not a correct definition of ultra-processed.

You can define it any way you want.

The words mean what we say they mean.