David Ghiyam
👤 SpeakerAppearances Over Time
Podcast Appearances
If it were genetic, it'd be static. The genes wouldn't suddenly become more prevalent in the population. So we take a step back and ask ourselves, well, what is really going on? Where are we in the understanding of what in the heck is going on? And let's look at health in general, and then we'll focus on Alzheimer's because general health and Alzheimer's are not disparate issues.
If it were genetic, it'd be static. The genes wouldn't suddenly become more prevalent in the population. So we take a step back and ask ourselves, well, what is really going on? Where are we in the understanding of what in the heck is going on? And let's look at health in general, and then we'll focus on Alzheimer's because general health and Alzheimer's are not disparate issues.
The same issues that are affecting the general health of the global population are at play in terms of undermining what's going on in the brain, making a good brain go bad, and it is In a word, metabolism. Metabolism is the main thing making a brain go bad. That's right. And it's not, it is not, I'll say it maybe three times, the accumulation of this protein called beta amyloid.
The same issues that are affecting the general health of the global population are at play in terms of undermining what's going on in the brain, making a good brain go bad, and it is In a word, metabolism. Metabolism is the main thing making a brain go bad. That's right. And it's not, it is not, I'll say it maybe three times, the accumulation of this protein called beta amyloid.
So what makes up a metabolism for a human being? Cells use energy and the progressive problems with our metabolic health are the number one cause of death on planet Earth. Really? Not COVID, not any other infectious disease, not war.
So what makes up a metabolism for a human being? Cells use energy and the progressive problems with our metabolic health are the number one cause of death on planet Earth. Really? Not COVID, not any other infectious disease, not war.
It is the progressive loss of metabolic function that underlies our chronic degenerative conditions like diabetes and various forms of cancer and heart disease and yes, Alzheimer's as well.
It is the progressive loss of metabolic function that underlies our chronic degenerative conditions like diabetes and various forms of cancer and heart disease and yes, Alzheimer's as well.
Totally glad that you asked that question. I feel like I scripted you to ask, and I'm going to respond to the nine-year-old. Because we all know that our cells are doing things. They're making proteins. They're clearing away waste products, etc.
Totally glad that you asked that question. I feel like I scripted you to ask, and I'm going to respond to the nine-year-old. Because we all know that our cells are doing things. They're making proteins. They're clearing away waste products, etc.
Every cell does something different in the human body, but to carry out any work, we have to have a fuel source and use that fuel to power the engine that allows the cell to do its thing. A car goes nowhere unless it has a battery pack or it uses gasoline. So it's the process of using fuel to carry out the various functions of the cell that we call metabolism.
Every cell does something different in the human body, but to carry out any work, we have to have a fuel source and use that fuel to power the engine that allows the cell to do its thing. A car goes nowhere unless it has a battery pack or it uses gasoline. So it's the process of using fuel to carry out the various functions of the cell that we call metabolism.
Now, if your car's metabolism is not working well, if for some reason, for example, you mixed your fuel with water or something, then the car is going to sputter and come to a screeching halt because it's metabolically compromised. That's what we are doing to the human brain. We are giving threats to the human brain that are compromising its ability to use fuel appropriately.
Now, if your car's metabolism is not working well, if for some reason, for example, you mixed your fuel with water or something, then the car is going to sputter and come to a screeching halt because it's metabolically compromised. That's what we are doing to the human brain. We are giving threats to the human brain that are compromising its ability to use fuel appropriately.
Now, by and large, the fuel is glucose. which is a good thing. Can the brain use fats? Can it use ketones for fuel? Yes, it can. So we really need to drill down on what's going on that allows the brain to use glucose. And where is the furnace? Where is it burning this glucose to produce energy? And it's doing so in parts of the cell organelles that are called Mitochondria.
Now, by and large, the fuel is glucose. which is a good thing. Can the brain use fats? Can it use ketones for fuel? Yes, it can. So we really need to drill down on what's going on that allows the brain to use glucose. And where is the furnace? Where is it burning this glucose to produce energy? And it's doing so in parts of the cell organelles that are called Mitochondria.
To a significant degree, yes. And mitochondria is in the brain? So mitochondria are little tiny organelles that live within the brain cells. Each brain cell may have, even though you see a diagram, here's the mitochondria, here are the ribosomes, here's the nucleus. Typically, a brain cell may have as many as a thousand mitochondria each cell.
To a significant degree, yes. And mitochondria is in the brain? So mitochondria are little tiny organelles that live within the brain cells. Each brain cell may have, even though you see a diagram, here's the mitochondria, here are the ribosomes, here's the nucleus. Typically, a brain cell may have as many as a thousand mitochondria each cell.
One cell. So how many mitochondria do we have in our brain? It's a number that is incalculable.
One cell. So how many mitochondria do we have in our brain? It's a number that is incalculable.