The School of Greatness
Neurologist: The Shocking ROOT CAUSE of Alzheimer’s - How To Prevent & REVERSE Damage To Your Brain | Dr. David Perlmutter
Mon, 25 Nov 2024
In today’s episode of The School of Greatness, I sit down with renowned neurologist and bestselling author Dr. David Perlmutter to explore the critical connection between metabolism and brain health. Dr. Perlmutter shares groundbreaking insights on preventing and potentially reversing Alzheimer's disease through metabolic health. As someone whose father suffered from Alzheimer's, he brings both scientific expertise and personal experience to this crucial conversation. We dive deep into how modern dietary habits are impacting our brain health, the promising research around GLP-1 agonists, and practical steps everyone can take to protect their cognitive function. Get ready for an eye-opening discussion that could change how you think about brain health and aging.Dr. Perlmutter's websiteIN THIS EPISODE YOU WILL LEARN:Why metabolism is the key driver of brain health and how mitochondrial function impacts cognitive declineThe surprising truth about fructose consumption and its effects on brain healthHow continuous glucose monitoring can help optimize your metabolic healthThe critical role of microglial cells in brain function and how to support their healthThe unexpected connection between birth delivery method and long-term health outcomesFor more information go to https://www.lewishowes.com/1698For more Greatness text PODCAST to +1 (614) 350-3960More SOG episodes we think you’ll love:Dr. Charan Ranganath – greatness.lnk.to/1632SCDr. William Li – greatness.lnk.to/1410SCGlucose Goddess – greatness.lnk.to/1575SC Get more from Lewis! Get my New York Times Bestselling book, Make Money Easy!Get The Greatness Mindset audiobook on SpotifyText Lewis AIYouTubeInstagramWebsiteTiktokFacebookX
Chapter 1: What is the main cause of Alzheimer's disease?
I think it's really important that people understand that Alzheimer's itself is the number three cause of death in America. It kills people. The rate of increase of Alzheimer's is far beyond the fact that our population is aging. One would expect that as the population ages, we would see an increase, but the rate of increase far exceeds that.
One of the most sought after minds on the planet in the fields of nutrition and brain health, four-time New York Times bestselling author, David Perlmutter.
One study demonstrated that there's a profound relationship between the number of sugary beverages and Alzheimer's risk and actual shrinkage of the brain. Really? The reality is that the metabolic defects of the brain begin 20 to 30 years prior to the clinical manifestations.
Is it possible to reverse dementia or Alzheimer's with newer mitochondria? to create a more present memory functioning brain?
The answer is absolutely.
Welcome back everyone at School of Greatness. Very excited about our guest. We have the inspiring Dr. David Perlmutter in the house. So good to see you, David. Thanks for being here again. Thanks for having me. Very excited about this because there's a massive health crisis in the world, specifically in America. It just seems to be growing and there's a stat
According to the Alzheimer Association, the number of Americans living with Alzheimer's is growing, and growing fast. Nearly 7 million Americans have Alzheimer's, and by 2050, the number of people age 65 and older with Alzheimer's may grow to a projected 12.7 million, barring the development of medical breakthroughs to prevent or cure Alzheimer's disease.
Now, you've written six New York Times bestselling books, 15 books in total. You're a neurologist, medical doctor specializing in the diagnosis and treating diseases of the brain, the spinal cord, and nerves. And I'm curious, what has been, in your opinion, or with the research that you've seen, the biggest cause of this spike in Alzheimer's over the last 20, 30 years? And
the fact that it just seems like it's just going to keep growing? What is the main causes of this? And is it bigger in America versus the rest of the world? Or is it kind of equal around the world?
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Chapter 2: Can Alzheimer's be reversed with new mitochondria?
Lewis, respectfully, it may not be the mission. I mean, I think oftentimes what we see is more interest in shareholders than stakeholders, basically that focus on the bottom line. And there was a resounding rejection of the approval process of a certain so-called Alzheimer's drug called Lekembe, still being, you know, editorials are written, why was this drug approved?
Because its clinical effectiveness after 18 months is minimal at best, and the side effect profile is very scary. So as we look at the risk-benefit ratio, it doesn't add up.
You mentioned processed foods, fructose, things that cause inflammation in the body. You know, obesity is one of the main, I guess, is something that's happening. I don't know what it is, 30 or 40% of America is kind of obese now, or is that what the calculation is?
I'd say it's close to 70 to 80% are either overweight or obese. Really? In fact, north of 90% of Americans have at least one component of metabolic dysfunction. And obesity is a big... Obesity, overweight, obesity is one of them. Certainly hypertension, elevated blood sugar, insulin resistance. These are all things that we consider. I add elevated uric acid to the equation as well.
This lipidemia or problems, abnormal lab studies as relates to our blood lipids. But having said that, only one or less than one in 10 individuals is metabolically intact in America today. And it's these metabolic issues that set the stage for all the things we don't want to get, including Alzheimer's disease.
And so a lot of these weight loss drugs are taking off because they have been effective in losing the weight, it seems like, for some people. And I haven't studied this enough to know the side effects or the harms of those. But you see cases of people losing a lot of weight quickly, it seems like.
What is more harmful, and maybe we don't have the research yet, but what is more harmful, being obese to our brain health or using a drug like an Ozempic to lose the inflammation on our body and the excess weight? But is there side effects that are causing more harm to the brain long term than the obesity?
You mean of using the drug?
Yeah. Like losing the weight, but staying on the drug or having obesity and not being on the drug. What is more harmful to the brain health?
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Chapter 3: What role does metabolism play in brain health?
We've covered a lot of water. I know. This is good though.
If someone dyes their hair. I guess you don't have the answer to this, but if someone dyes their hair with over-the-counter normal hair dye, I guess, are they hurting the functionality of their hair? quality, strength, and color by doing that? Or is it not hurting that in the research that we have so far?
Hard to say because inherent in the ability to dye hair is first stripping it and allowing so that the dye then is more able to penetrate the hair. Is that necessarily good for hair? I tend to think that it is not. Got it. Okay. So, you know, we've gone from inside the head to outside the head.
I don't know how it's impacting. I'm just curious. Yet it's exceedingly common. Did you used to dye your hair ever? Never have. Never have?
No.
Not even a little like just for man on the sides or something? Never went with it. You know, I'm okay with it. I'm just fine with it. Yeah, yeah. Yeah. There was a clip that we posted the last time we had you on that went crazy on Facebook. And my team told me that it was... That's something I remember to tell you. Go ahead. Okay.
My team told me that it was our most watched clip on all of our Facebook videos from you. And I wanted to follow up and see if there's more research from what we talked about. And the clip that we talked about that went crazy online was around... the pros and cons of having a vaginal birth for mothers versus a cesarean C-section for mothers.
And you mentioned something about kind of the pros and cons of the immune health of the child, however they're being birthed. And I don't know if you remember this. Oh, I do. And if you can elaborate on the pros and cons of a C-section versus a vaginal birth.
And I understand there's certain complications these days for women needing to have a C-section for whatever reason, but is there research on the pros and cons of vaginal versus cesarean section births? And if someone has to do a C-section for whatever complicational reasons, Is there a way that you can still benefit the child so that they get the optimal immune capacity from that birth?
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