David Ghiyam

I'm going to challenge you a little bit here. Okay. And because it challenged me quite a bit as well. So You know, obesity is not just an accumulation of body fat. There's a lot going on with obesity in terms of letting us understand that metabolism is really in disarray. Obesity is really kind of the outward manifestation of what I call metabolic mayhem.

I'm going to challenge you a little bit here. Okay. And because it challenged me quite a bit as well. So You know, obesity is not just an accumulation of body fat. There's a lot going on with obesity in terms of letting us understand that metabolism is really in disarray. Obesity is really kind of the outward manifestation of what I call metabolic mayhem.

There's a lot going on with obesity beyond just the presence of body fat. We know that mitochondria are threatened. We know that inflammation markers are skyrocketing. We know that there's an increased leakiness of the bowel. We know that risk for neurodegenerative conditions is going up. Diabetes, of course.

There's a lot going on with obesity beyond just the presence of body fat. We know that mitochondria are threatened. We know that inflammation markers are skyrocketing. We know that there's an increased leakiness of the bowel. We know that risk for neurodegenerative conditions is going up. Diabetes, of course.

so it all date it all dates back to or gets back to the issue with metabolic and the threat that is evident when someone is obese or hypertensive or has elevated blood sugar because they're insulin resistant it's an indication that their metabolism is dysfunctional that is a clear and present danger to the brain so

so it all date it all dates back to or gets back to the issue with metabolic and the threat that is evident when someone is obese or hypertensive or has elevated blood sugar because they're insulin resistant it's an indication that their metabolism is dysfunctional that is a clear and present danger to the brain so

What happens if you take one of these GLP-1 agonist drugs, like semaglutide, like ozempic, or liraglutide, and lose the weight? What's happening? Is that a good thing or is it a bad thing? That's what your question is, isn't it? Yes. And you're expecting a particular answer from you. I'm not expecting any answer. I'm curious of your response.

What happens if you take one of these GLP-1 agonist drugs, like semaglutide, like ozempic, or liraglutide, and lose the weight? What's happening? Is that a good thing or is it a bad thing? That's what your question is, isn't it? Yes. And you're expecting a particular answer from you. I'm not expecting any answer. I'm curious of your response.

And I think you're going to be surprised by where we go with this. Because what these drugs have been shown to do is... Nothing short of remarkable in terms of metabolism. So they were originally developed to help people lower their blood sugar to improve the way we're able to control our blood sugar.

And I think you're going to be surprised by where we go with this. Because what these drugs have been shown to do is... Nothing short of remarkable in terms of metabolism. So they were originally developed to help people lower their blood sugar to improve the way we're able to control our blood sugar.

And it was almost as a side effect initially that people noticed that their weight was going down. And now, of course, they've been repurposed and subsequently approved for weight loss. But there is a lot going on with metabolism as a consequence of GLP agonist drugs.

And it was almost as a side effect initially that people noticed that their weight was going down. And now, of course, they've been repurposed and subsequently approved for weight loss. But there is a lot going on with metabolism as a consequence of GLP agonist drugs.

And I am not... You know, generally my mission in life is not pharmacocentric.

And I am not... You know, generally my mission in life is not pharmacocentric.

You know, I want to allow people, and we're going to morph back to that in just a moment, but the reason we're going to unpack this GLP-1 agonist drug and why it's having positive effects in the brain is because it will subsequently, again, allow us to circle back to the primacy of metabolic issues as it relates to brain health. Here's a powerful validation.

You know, I want to allow people, and we're going to morph back to that in just a moment, but the reason we're going to unpack this GLP-1 agonist drug and why it's having positive effects in the brain is because it will subsequently, again, allow us to circle back to the primacy of metabolic issues as it relates to brain health. Here's a powerful validation.

So the GLP-1 drugs do far more than help us control our blood sugar and lose weight. They focus on metabolism. They actually enhance mitochondrial function. Really? Can you believe it? I mean, most of the work has been done in diabetic patients.

So the GLP-1 drugs do far more than help us control our blood sugar and lose weight. They focus on metabolism. They actually enhance mitochondrial function. Really? Can you believe it? I mean, most of the work has been done in diabetic patients.

but showing reduced free radical formation, increased oxygen consumption, in other words, an improvement in mitochondrial function, which requires oxygen for the burning of the fuel, and various other metabolic markers that are improved in diabetic patients who have been prescribed these medications.

but showing reduced free radical formation, increased oxygen consumption, in other words, an improvement in mitochondrial function, which requires oxygen for the burning of the fuel, and various other metabolic markers that are improved in diabetic patients who have been prescribed these medications.