David Ghiyam

It doesn't help mitochondria. No, it doesn't.

It doesn't help mitochondria. No, it doesn't.

And I would say that on occasion I stay up too late. When I get to a place of being deeply involved in research, I can't turn it off. Yeah, it's hard. I cannot turn it off. And I know I should go to bed, and my wife tells me I need to go to bed because she is... Remember, you just said this on a podcast. Yeah, it's like...

And I would say that on occasion I stay up too late. When I get to a place of being deeply involved in research, I can't turn it off. Yeah, it's hard. I cannot turn it off. And I know I should go to bed, and my wife tells me I need to go to bed because she is... Remember, you just said this on a podcast. Yeah, it's like...

I know, but sometimes I'm so close to discovering something and pulling things in, I just can't lose the thread.

I know, but sometimes I'm so close to discovering something and pulling things in, I just can't lose the thread.

Well, I think that tends to generalize. We do know that there are some individuals who are able to sleep five to six hours and do quite well. And again, there's no magic of the eight hours. We know that Alzheimer's risk is increased in people who have shorter duration of sleep and who have longer duration of sleep as well.

Well, I think that tends to generalize. We do know that there are some individuals who are able to sleep five to six hours and do quite well. And again, there's no magic of the eight hours. We know that Alzheimer's risk is increased in people who have shorter duration of sleep and who have longer duration of sleep as well.

That once we get north of nine hours of sleep, Alzheimer's risk goes back up. So it's a bit of a U-shaped curve. But I think that what the data, what Matthew Walker has talked about in his really wonderful book, Why We Sleep, is there are a variety of issues.

That once we get north of nine hours of sleep, Alzheimer's risk goes back up. So it's a bit of a U-shaped curve. But I think that what the data, what Matthew Walker has talked about in his really wonderful book, Why We Sleep, is there are a variety of issues.

I mean, one thing that we see when we don't sleep enough that I think is really fundamental is that inflammatory chemicals, cytokines, seem to increase. The very next morning, we've lit up the amygdala the impulsive fear mongering part of the brain, the child in the room, the poor decision maker and as such our decision making is threatened dramatically. Wow.

I mean, one thing that we see when we don't sleep enough that I think is really fundamental is that inflammatory chemicals, cytokines, seem to increase. The very next morning, we've lit up the amygdala the impulsive fear mongering part of the brain, the child in the room, the poor decision maker and as such our decision making is threatened dramatically. Wow.

Such that when you look at the type of food choices a person will make when he or she is deprived of sleep for a night, it's dramatic. The caloric consumption that happens and the quality of the food that people will consume and even

Such that when you look at the type of food choices a person will make when he or she is deprived of sleep for a night, it's dramatic. The caloric consumption that happens and the quality of the food that people will consume and even

Other measurements of decision-making quality in studies, which are correlated, interestingly, with functional MRI evaluation of the activity of their brain's amygdala, the fear center, the poor decision maker. So that's something people don't really talk about. I mean, what people are really talking about these days is the activation in the brain. And this is important.

Other measurements of decision-making quality in studies, which are correlated, interestingly, with functional MRI evaluation of the activity of their brain's amygdala, the fear center, the poor decision maker. So that's something people don't really talk about. I mean, what people are really talking about these days is the activation in the brain. And this is important.

I don't mean to minimize it. of basically the ability of the brain to clear itself out. The brain has a lymphatic system as well called the glymphatic system, and it's during sleep, during deep sleep, that our brains are able to rid themselves of accumulated things that happen during the course of the day or through our exposure. So that's certainly very important.

I don't mean to minimize it. of basically the ability of the brain to clear itself out. The brain has a lymphatic system as well called the glymphatic system, and it's during sleep, during deep sleep, that our brains are able to rid themselves of accumulated things that happen during the course of the day or through our exposure. So that's certainly very important.

So, you know, the other thing that happens, I think there's really very relevant gets back to dead center to our conversation is with repeated lack of restorative sleep. It's a powerful threat to metabolism and mitochondrial function.

So, you know, the other thing that happens, I think there's really very relevant gets back to dead center to our conversation is with repeated lack of restorative sleep. It's a powerful threat to metabolism and mitochondrial function.