David Ghiyam

That may happen, but I think that eating sugar actually immediately stimulates the body to produce GLP-1, as does fat and fiber.

That may happen, but I think that eating sugar actually immediately stimulates the body to produce GLP-1, as does fat and fiber.

So this glucagon-like peptide, is when we're eating, there's a lot of signaling going on in the body that suddenly there's a big change about to occur. We're gonna load the body up with who knows what and how are we going to deal with it and how much should we be consuming and why don't we just keep eating? So this is a way of regulating appetite that's built into our physiology.

So this glucagon-like peptide, is when we're eating, there's a lot of signaling going on in the body that suddenly there's a big change about to occur. We're gonna load the body up with who knows what and how are we going to deal with it and how much should we be consuming and why don't we just keep eating? So this is a way of regulating appetite that's built into our physiology.

that now starts to metricize what we're eating in terms of quantity and quality, in terms of calories derived from fat versus carbohydrate, so that we're going to eat an appropriate amount of food. Other hormones are involved, like ghrelin and leptin as well. With time, we can become less sensitive to these chemicals.

that now starts to metricize what we're eating in terms of quantity and quality, in terms of calories derived from fat versus carbohydrate, so that we're going to eat an appropriate amount of food. Other hormones are involved, like ghrelin and leptin as well. With time, we can become less sensitive to these chemicals.

We certainly become less sensitive to leptin, which also regulates our appetite. Like we can become insulin resistant, we can become leptin resistant as we constantly bombard our bodies with foods that challenge the production of leptin, we become resistant. So we become less sensitive to the signaling of leptin and therefore we might eat too much.

We certainly become less sensitive to leptin, which also regulates our appetite. Like we can become insulin resistant, we can become leptin resistant as we constantly bombard our bodies with foods that challenge the production of leptin, we become resistant. So we become less sensitive to the signaling of leptin and therefore we might eat too much.

I mean, there was an attempt in the past to give people leptin as a way of curbing their appetites, didn't seem to work.

I mean, there was an attempt in the past to give people leptin as a way of curbing their appetites, didn't seem to work.

but clearly the glp-1 agonists are working i mean um people aren't just taking these drugs because they're uh you know they're being the celebrities are talking about them they're working uh extremely effectively in terms of weight loss and in control of blood sugar as well in the new york times this morning was a fascinating article

but clearly the glp-1 agonists are working i mean um people aren't just taking these drugs because they're uh you know they're being the celebrities are talking about them they're working uh extremely effectively in terms of weight loss and in control of blood sugar as well in the new york times this morning was a fascinating article

talking about addiction and the effectiveness of GLP-1 agonist drugs in terms of addiction, even things like alcohol consumption.

talking about addiction and the effectiveness of GLP-1 agonist drugs in terms of addiction, even things like alcohol consumption.

Actually, they slow gastric emptying so that that food will be around longer and will then be available for digestion perhaps longer. But I think the former is probably much more a reason that we just, our appetites are curbed and we're eating less food.

Actually, they slow gastric emptying so that that food will be around longer and will then be available for digestion perhaps longer. But I think the former is probably much more a reason that we just, our appetites are curbed and we're eating less food.

Yeah, and the stomach, because it's not emptying, becomes more distended, and that is an electrical event. We sense that the stomach is becoming distended, and as such, it sends a signal to the brain that we should stop eating.

Yeah, and the stomach, because it's not emptying, becomes more distended, and that is an electrical event. We sense that the stomach is becoming distended, and as such, it sends a signal to the brain that we should stop eating.

In days gone by, a procedure was done called a gastric sleeve, where the outflow of the stomach was compressed with a device, and as such, the stomach would then distend more, and that would send signals to the brain doing the same type of thing.

In days gone by, a procedure was done called a gastric sleeve, where the outflow of the stomach was compressed with a device, and as such, the stomach would then distend more, and that would send signals to the brain doing the same type of thing.