Derek (More Plates More Dates)

I think most people would say it's the high of normal because that's literally what it is on a reference range.

So, it all is going to be just being cognizant of the fact that androgens will do what androgens do, which is they will, in a dose-dependent manner, derive erythropoiesis.

They will...

induce cardiac remodeling if you push it too hard not necessarily within physiologic limits but like these are things to be aware of dyslipidemia will become more of a concern at a higher level especially depending on the medium of administration if you're dosing infrequently like once a week with a shot it's going to be a different outcome than if you're doing like daily you know little pulsatile uh cream administrations or like micro injections like subcutaneously where you're bleeding out the effect more

it will all be impactful.

So I think it's more about, there is a risk, all but there's not gonna be data that says directly, if you replace to 800 total T, it's going to be dangerous, nor is there data that says it's safe either.

Like you can kind of take from the Traverse trial what they found,

and extrapolate out like what you know from graded dose response studies, which do exist and like realize, okay, like somewhere in the middle here, if you're one of those guys who like wants to hit that, you know, high normal, because I don't know, like who's to say you're in the wrong for wanting to be like optimally vital too.

It all kind of depends on the person.

You have to weigh the risk accordingly because it's not risk-free.

You're still gonna have to keep an eye on your hematology panel.

is it getting out of whack to a degree that is like unsustainable?

You're like looking at phlebotomy is just to maintain something that looks normal.

Or is it like,

Adequate slash like optimal for you now to feel like you have enough energy to not like faint when you get up It depends on the person Yeah, it's just like an understanding of all of the interplay of things and not taking the sign off You know the one the traverse trial is like, you know, you're get a jail-free card Like it's just you're still gonna have to keep an eye on your blood work you're still gonna have to have like a doctor who knows what they're talking about and is like very rigorous about this stuff and

You have to know how the different administration methods and frequency will impact things because like you're probably not going to be on androgel using a little dose that gets you to 420 nanograms per deciliter.

you're probably not on that protocol.

And if you are like, yeah, okay, look at the traverse trial.

And like, maybe you can get like a bit more reassurance, but like, you're probably not that guy.

And that's fine.