Dominic D'Agostino

The thing was just eating all fat.

And then we realized we got to titrate in the protein to prevent protein malnutrition.

And then there was a tiny, in 1921, in a clinical, it was just like a side note on a clinical journal, the first observation or clinical report of a ketogenic diet used in epilepsy and the remarkable effects.

And we didn't have anything.

I mean, we could go a hundred years later and we don't fully grasp and understand all the mechanisms involved.

And that's why it's such a fruitful, robust area of research right now with drug companies scrambling to mimic.

If we had a drug that would mimic the ketogenic diet, it would be a blockbuster drug.

In the context of pediatric epilepsy, about two-thirds will be, so it's that high.

Two-thirds will be?

to a ketogenic diet therapy for managing seizures, are highly efficacious for managing seizures.

Two-thirds of people who have failed drug therapy, we're not just talking about one drug.

We're talking about polypharmacy, adding multiple drugs.

The list goes on.

What about adults?

So in adults, it's more about closer to post-adolescence, about 30 to 40%.

But then it's thought that adherence and compliance with adolescents, with kids, the parents feed usually a ketogenic formula and calculate it out.

But there's also something about the pediatric brain that's probably more responsive.

And then of that two thirds, about one third have like complete seizure control, 95 to 100% seizure control.

And then 10 to 15%, and this really interested me when I went to the first conferences back maybe 15 years ago, were super responders, meaning that they could get on a ketogenic diet,

follow it for a year or two, transition off and never get seizures again.