Dominic D'Agostino

However, I say there's a hard stop there.

The ketogenic diet is indeed a magical diet in the way that it remarkably changes our physiology.

And there's no other diet that exists that can, for example, manage drug-resistant seizures.

And it does that because it profoundly changes our fuel system, our physiology, our biochemistry, and our neuropharmacology.

And if I'm not mistaken... Adults, actually, if you go back to the Mayo Clinic in 1920s, because there was no drugs for epilepsy.

So...

Yeah.

Yeah.

They actually did some really good physiology back in the 1930s, 40s.

Underappreciated.

Well, we knew that fasting controlled seizures.

So that was the first observation.

Yeah.

I mean, Gospel of Mark talks about fasting.

I mean, it's all over like in the literature.

Fasting could control seizures.

So a ketogenic diet, by virtue of elevating these ketone bodies, which were showing up in the blood and the urine and even in the breath, they just understood that these ketone bodies were somehow associated with seizure control.

And we did not have anti-seizure drugs back then.

Within a decade around that time, with Banting and Best, discovered it in the context of diabetic ketoacidosis, and then worked at the Mayo Clinic by Wilder and a few other people were helping sort of establish the framework for what would be ultimately the first ketogenic diet therapies.

And