Dominic D'Agostino

with the free acid because you could buy it and it's super acidic and it's not very stable in solution.

And for a variety of different reasons, although you could put free acid, it needs to be liquid into like an electrolyte formulation.

So we gravitated towards, at the time I was using in my electrophysiology experiments, you can't put a ketone ester in the bath because it needs to be metabolized by the liver.

So you can't put it onto neurons.

So you have to use the salt.

So you mimic the pharmacokinetics of what you get with the ester.

So we were putting sodium beta-hydroxybutyrate in.

I was thinking, okay, I'll give this to the animals.

But then it was like, I was very concerned with the sodium overload, hypertension, all the negative effects about salt.

But all the negative effects about salt, and your listeners may not know this, but most physiologists kind of do that study at the salt sensitive people or the problem with salts is

and people maybe even think ketone salts, is that when you consume salt, you get hypertension in some people, salt-sensitive.

But that's specific to sodium chloride.

So sodium bicarb, sodium citrate, sodium beta-hydroxybutyrate is what I'm talking about.

If you consume large doses, gram molecules of that, that doesn't have the same hypertension.

Something about chloride.

So sodium chloride.

So you could use potassium chloride instead of sodium chloride for

But I think that's an important thing to consider because a lot of people shy away from ketone salts because it's sodium.

But the salt-sensitive hypertension that you get is pretty much associated with sodium chloride.

And I was communicating with Patrick Arnold at the time, and I was like, I have sodium chloride, but I wanted to get potassium chloride.