Dominic D'Agostino

So now you have L enriched formulations with D. But we've always kind of stuck with the racemic mixtures because I kind of knew that there was fundamentally something

Interesting about the D and the L, because when I use pure D beta-hydroxybutyrate, it actually trended to make seizures happen faster, and I didn't know why.

Say that again?

When we use pure beta-hydroxybutyrate, the D enantiomer, and with an ester, like the monoester...

Yep.

1,3-butanediol and then the monoester had no effect on seizures.

So my colleague, Dr. Jung Ro said, you need to look at acetoacetate.

And when you elevate acetoacetate,

beta-hydroxybutyrate and acetoacetate in a one-to-one ratio, that creates a redox balance.

And I do think that's important.

Also, people brought to my attention that when you rapidly spike D-beta-hydroxybutyrate, you're causing something called reductive stress.

So you have the production of NADH from NADH.

And that's actually depleting NAD.

A ketogenic diet will boost your NAD.

You could take NAD supplements.

That's something that we're working on too, because I think a central mechanism in ketogenic diets and supplements is the elevation of NAD.

So we're working with NAD compounds.

I can't talk about that because it's through an industry, but there are multiple compounds of stabilized NAD.

that have interesting and remarkable effects.

And we're going to combine them with various new ketone molecules that we're developing.