The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
I believe from what I last heard, I can't talk about it too much, but I think some of the data is very encouraging.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
There was case reports that combined a ketogenic diet with
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
ketamine and that put anorexia into remission and there's been quite a bit of buzz about that and for anorexia typically you steer people away from any kind of dietary restriction yeah that would be traditional thinking yeah but the effects of the ketogenic diet on neuropharmacology on the hedonic response on stabilizing your mood and other factors that could play into anorexia
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
seem to be at play.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
I was super skeptical because it flies in the face of everything that I know.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
We have one of the leading experts at University of South Florida, Deanna Ranquart.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
I remember talking to her about it, and she was a little bit skeptical, but the data coming out looks very promising and compelling.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
So there's continuing emerging data on psychiatric disorders, largely funded by the Bazooki Group, I think exclusively funded by Jan and David Bazooki, their foundation.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
And I think they're funding million-dollar studies at
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
Six of them that I know, you have Ohio State University, Stanford, Oxford, Stony Brook, UCSD, UCLA, I think Edinburgh, there's a study too.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
I'm just looking at the different applications.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
So they're funding many different studies, mostly across severe psychiatric disorders.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
Primarily the ketogenic diet, although having served as a reviewer because they have a study section.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
In the pipeline of emerging studies that they're funding, I would say quite a few studies will be incorporating exogenous ketone supplementation.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
So they see that as an innovative approach and a necessary approach for the feasibility of therapeutic ketosis because with a psychiatric disorder, it's really difficult to get someone to adhere to a ketogenic diet with bipolar, with schizophrenia.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
I mean, it's like a nightmare.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
It depends.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
People don't like that answer.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
And it's also very context dependent.
The Peter Attia Drive
#375 - The ketogenic diet, ketosis, and hyperbaric oxygen: metabolic therapies for weight loss, cognitive enhancement, cancer, Alzheimer's disease, brain injuries, and more | Dominic D'Agostino, Ph.D.
But I'll say this, that there are benefits that you get from carbohydrate restriction that cannot be replicated with exogenous ketone supplementation.