Dominic D'Agostino

I think that's important.

So higher ketones, it's like we're not shooting to get our glucose to like 7, 8 millimolars.

There's very powerful homeostatic mechanisms that maintain glucose under normal conditions.

If we're jacking up our ketones above 2, once you get above 2 to get the 3, 4, and 5, then you're approaching energy toxicity.

So you have a level of ketones in your blood that's producing energy toxicity.

Energy toxicity is defined by...

An elevation of a metabolite circulating in your blood that is causing a number of things.

One is a counter-regulatory reaction, which means it's increasing the release of insulin, the secretion of insulin.

And your kidneys have to dispose of that.

And our blood gases and blood pH, blood pH will start to go down.

Your blood will become more acidic.

That's not a good thing.

Above 2, pretty much always kind of above 2, maybe 3, in the context of supplemental ketosis.

So if you're on a ketogenic diet and your glucose is so low, your levels of ketones may approach 3 or 4 because of the glucose deficiency that you have in your body.

So fat oxidation is so high, it's a very elegant and finely tuned response that you have.

Yeah.

I mean, you have respiratory and renal compensation.

And that's not hard at all for you to do.

So if you're consuming large doses of exogenous ketones, this is not applied to the ketone salts because the salt is actually a natural buffer.

So that's the ionic bond is a positive and a negative.