Dominic D'Agostino

So you just dose that a couple times.

But also, some of the problems that we talked about with fast entry of ketones into the bloodstream with the ketone esters or 1,3-beta-ken, if you formulate that with MCT or

which we've published on that, that can mitigate some of the negative effects.

So we don't see, you can mitigate the toxicity, at least in animal models.

You need to appreciate the rate of rise of ketones is that's kind of the trigger for some of the counter-regulatory effects, more like a dosing issue.

I would say for people that have normal physiology, no kidney, or maybe even with impaired kidney function because ketocitra is sold.

I think a study just came out with beta-hydroxybutyrate citrate and other electrolytes too for kidney disorders.

But generally, no.

So I was concerned that sodium would cause hypertension.

But sodium chloride seems to be the major player there.

So I would say no, but also do your blood work.

I haven't seen that.

And that was one of the early concerns I had.

Actually, it steered me toward developing something other than sodium to potassium and calcium and other things.

So electrolytes are largely benign unless you're above the 10 grams per day kind of issue.

And I think even with sodium, the guidelines are something like 5 grams of sodium per day, like dietary sodium.

But then something just came out that said that should probably be more like 8 to 10 grams.

Which guideline?

The guidelines right now, I think, cap it at five grams of sodium.

Yeah.