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Dr. Abraham Morgentaler

๐Ÿ‘ค Speaker
944 total appearances

Appearances Over Time

Podcast Appearances

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

How many doctors were around who had a large population of eunuchs that they would follow for 50 years or so until they were in their 70s or 80s and decided, yep, there's no cancer? Nobody. I mean, it's not real, but that was a story. And so these were men that we were biopsying before testosterone. And the only reason we were biopsying them was because they had low testosterone.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

How many doctors were around who had a large population of eunuchs that they would follow for 50 years or so until they were in their 70s or 80s and decided, yep, there's no cancer? Nobody. I mean, it's not real, but that was a story. And so these were men that we were biopsying before testosterone. And the only reason we were biopsying them was because they had low testosterone.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

PSA normal, digital rectal exam normal. And we found prostate cancer right away.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

PSA normal, digital rectal exam normal. And we found prostate cancer right away.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

PSA normal, digital rectal exam normal. And we found prostate cancer right away.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

This was called, it was a sextant biopsy. We only took six cores back then, and it was totally random. Ultrasound guided, but random. And one out of seven of these men had prostate cancer. Most were Gleason 6, which we were still worried about back then, seriously worried. And some of them were Gleason 7.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

This was called, it was a sextant biopsy. We only took six cores back then, and it was totally random. Ultrasound guided, but random. And one out of seven of these men had prostate cancer. Most were Gleason 6, which we were still worried about back then, seriously worried. And some of them were Gleason 7.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

This was called, it was a sextant biopsy. We only took six cores back then, and it was totally random. Ultrasound guided, but random. And one out of seven of these men had prostate cancer. Most were Gleason 6, which we were still worried about back then, seriously worried. And some of them were Gleason 7.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And I'll tell you this little story because I think it tells us a little bit about how things work. So I had 50 patients. Now, that's not a ton, but these were probably the first 50 patients that underwent prostate biopsy because they had low testosterone. So I was hoping to treat them if their biopsies came back negative.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And I'll tell you this little story because I think it tells us a little bit about how things work. So I had 50 patients. Now, that's not a ton, but these were probably the first 50 patients that underwent prostate biopsy because they had low testosterone. So I was hoping to treat them if their biopsies came back negative.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And I'll tell you this little story because I think it tells us a little bit about how things work. So I had 50 patients. Now, that's not a ton, but these were probably the first 50 patients that underwent prostate biopsy because they had low testosterone. So I was hoping to treat them if their biopsies came back negative.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

and submitted the paper, and I've published my share of papers, and this never happened to me before or since, which is that one of the editors called me on the telephone and said, you know, our editorial board just discussed your manuscript, and it's very interesting. It shows the opposite of what everybody has believed. You have a group of men with low testosterone, high rates,

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

and submitted the paper, and I've published my share of papers, and this never happened to me before or since, which is that one of the editors called me on the telephone and said, you know, our editorial board just discussed your manuscript, and it's very interesting. It shows the opposite of what everybody has believed. You have a group of men with low testosterone, high rates,

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

and submitted the paper, and I've published my share of papers, and this never happened to me before or since, which is that one of the editors called me on the telephone and said, you know, our editorial board just discussed your manuscript, and it's very interesting. It shows the opposite of what everybody has believed. You have a group of men with low testosterone, high rates,

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Of prostate cancer. So we're interested in this. It's very curious. But you know, you only have 50 men. And I tell you what, if you accumulate more men and you do biopsies on them and the numbers hold up, please resubmit your paper and we'll consider it very seriously. So when I had 77 guys, I resubmitted it and it got published in the Journal of the American Medical Association in 1996.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Of prostate cancer. So we're interested in this. It's very curious. But you know, you only have 50 men. And I tell you what, if you accumulate more men and you do biopsies on them and the numbers hold up, please resubmit your paper and we'll consider it very seriously. So when I had 77 guys, I resubmitted it and it got published in the Journal of the American Medical Association in 1996.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Of prostate cancer. So we're interested in this. It's very curious. But you know, you only have 50 men. And I tell you what, if you accumulate more men and you do biopsies on them and the numbers hold up, please resubmit your paper and we'll consider it very seriously. So when I had 77 guys, I resubmitted it and it got published in the Journal of the American Medical Association in 1996.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And that was the first time that, and it was clear then, that low testosterone was not protective. And we followed that up a few years later as I started doing more of this with another 345 men and the results were identical. So part of the story was BS. Low testosterone was not protective. These guys had as high rate as prostate cancer as anybody.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And that was the first time that, and it was clear then, that low testosterone was not protective. And we followed that up a few years later as I started doing more of this with another 345 men and the results were identical. So part of the story was BS. Low testosterone was not protective. These guys had as high rate as prostate cancer as anybody.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And that was the first time that, and it was clear then, that low testosterone was not protective. And we followed that up a few years later as I started doing more of this with another 345 men and the results were identical. So part of the story was BS. Low testosterone was not protective. These guys had as high rate as prostate cancer as anybody.