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Dr. Abraham Morgentaler

๐Ÿ‘ค Speaker
944 total appearances

Appearances Over Time

Podcast Appearances

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And it's important for the doctor to know that and also very useful to let the patient know that. Because when it comes back at a month or two months or three months, if you don't tell them, everybody's going to worry that the cancer is growing. So it's expected to go up if the testosterone was less than 250. And the new value at about three months becomes the new baseline.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And it's important for the doctor to know that and also very useful to let the patient know that. Because when it comes back at a month or two months or three months, if you don't tell them, everybody's going to worry that the cancer is growing. So it's expected to go up if the testosterone was less than 250. And the new value at about three months becomes the new baseline.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And it's important for the doctor to know that and also very useful to let the patient know that. Because when it comes back at a month or two months or three months, if you don't tell them, everybody's going to worry that the cancer is growing. So it's expected to go up if the testosterone was less than 250. And the new value at about three months becomes the new baseline.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

That's the true baseline. And we only worry if it goes up from there in a consistent way.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

That's the true baseline. And we only worry if it goes up from there in a consistent way.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

That's the true baseline. And we only worry if it goes up from there in a consistent way.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Correct. And the funny thing is, is that even though we've been taught, it's been drilled into us, testosterone is dangerous, testosterone is dangerous. Most prostate cancer guys, they don't measure a testosterone. They don't even know what a testosterone is. They don't know whether it's normal or low.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Correct. And the funny thing is, is that even though we've been taught, it's been drilled into us, testosterone is dangerous, testosterone is dangerous. Most prostate cancer guys, they don't measure a testosterone. They don't even know what a testosterone is. They don't know whether it's normal or low.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Correct. And the funny thing is, is that even though we've been taught, it's been drilled into us, testosterone is dangerous, testosterone is dangerous. Most prostate cancer guys, they don't measure a testosterone. They don't even know what a testosterone is. They don't know whether it's normal or low.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And that's not a criticism of them because the truth is, it doesn't really matter for the outcomes we care about with prostate cancer. It doesn't really matter.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And that's not a criticism of them because the truth is, it doesn't really matter for the outcomes we care about with prostate cancer. It doesn't really matter.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And that's not a criticism of them because the truth is, it doesn't really matter for the outcomes we care about with prostate cancer. It doesn't really matter.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Well, it matters if they're symptomatic and you're thinking about giving them testosterone afterwards, for sure. Yeah. And then you have to, if you're using PSA, you have to know whether the testosterone has let the PSA max out to whatever it's going to be, or if it's somewhat inhibited because testosterone is too low.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Well, it matters if they're symptomatic and you're thinking about giving them testosterone afterwards, for sure. Yeah. And then you have to, if you're using PSA, you have to know whether the testosterone has let the PSA max out to whatever it's going to be, or if it's somewhat inhibited because testosterone is too low.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Well, it matters if they're symptomatic and you're thinking about giving them testosterone afterwards, for sure. Yeah. And then you have to, if you're using PSA, you have to know whether the testosterone has let the PSA max out to whatever it's going to be, or if it's somewhat inhibited because testosterone is too low.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Yeah. So it was one of the great advances in testosterone therapy is the development of these oral medications, pills for testosterone. And, you know, we used to say until they came about, maybe about, what, three, four years ago, that oral testosterone was bad. And the reason we said it is because they were alkylated. They had a side chain.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Yeah. So it was one of the great advances in testosterone therapy is the development of these oral medications, pills for testosterone. And, you know, we used to say until they came about, maybe about, what, three, four years ago, that oral testosterone was bad. And the reason we said it is because they were alkylated. They had a side chain.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

Yeah. So it was one of the great advances in testosterone therapy is the development of these oral medications, pills for testosterone. And, you know, we used to say until they came about, maybe about, what, three, four years ago, that oral testosterone was bad. And the reason we said it is because they were alkylated. They had a side chain.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And when you swallowed them, it had a first pass effect with the liver and it turned out to have some liver toxicity. The new pills are all made out of testosterone undecanoate, which has this long carbon side chain of 11 carbons. And it doesn't get absorbed the usual way through the gastric and through the intestinal vasculature, but rather it gets absorbed through the lymphatics.

BackTable Urology
Ep. 188 Testosterone Therapy Today: Clinical Advances and Safety with Dr. Abraham Morgentaler

And when you swallowed them, it had a first pass effect with the liver and it turned out to have some liver toxicity. The new pills are all made out of testosterone undecanoate, which has this long carbon side chain of 11 carbons. And it doesn't get absorbed the usual way through the gastric and through the intestinal vasculature, but rather it gets absorbed through the lymphatics.