Dr. Abraham Morgentaler
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And when you swallowed them, it had a first pass effect with the liver and it turned out to have some liver toxicity. The new pills are all made out of testosterone undecanoate, which has this long carbon side chain of 11 carbons. And it doesn't get absorbed the usual way through the gastric and through the intestinal vasculature, but rather it gets absorbed through the lymphatics.
And so it bypasses the liver altogether and doesn't have toxicity. The product that I'm most familiar with is called Kisotrex. They're all made out of testosterone and decanoate. And what's nice about the pills are that... You know, the most popular treatment for the last, I don't know, 7 to 10 years with testosterone have been injections. People learn to inject themselves.
And so it bypasses the liver altogether and doesn't have toxicity. The product that I'm most familiar with is called Kisotrex. They're all made out of testosterone and decanoate. And what's nice about the pills are that... You know, the most popular treatment for the last, I don't know, 7 to 10 years with testosterone have been injections. People learn to inject themselves.
And so it bypasses the liver altogether and doesn't have toxicity. The product that I'm most familiar with is called Kisotrex. They're all made out of testosterone and decanoate. And what's nice about the pills are that... You know, the most popular treatment for the last, I don't know, 7 to 10 years with testosterone have been injections. People learn to inject themselves.
But the truth is a lot of people don't want to inject, right? Nobody looks forward to it. It may be worth it to them, but nobody looks forward to it. And people are used to pills. We take pills for all sorts of things, Tylenol for headaches and whatever else. And so the pills are taken twice daily. They all have different dosages.
But the truth is a lot of people don't want to inject, right? Nobody looks forward to it. It may be worth it to them, but nobody looks forward to it. And people are used to pills. We take pills for all sorts of things, Tylenol for headaches and whatever else. And so the pills are taken twice daily. They all have different dosages.
But the truth is a lot of people don't want to inject, right? Nobody looks forward to it. It may be worth it to them, but nobody looks forward to it. And people are used to pills. We take pills for all sorts of things, Tylenol for headaches and whatever else. And so the pills are taken twice daily. They all have different dosages.
For Kisotrex, the usual starting dose that most urologists are using now is 400 BID. So it's two of the 200 pills taken twice a day. The testosterone levels go up and then they drop. And then you take it again and it goes up and it goes down. And the symptomatic response is excellent.
For Kisotrex, the usual starting dose that most urologists are using now is 400 BID. So it's two of the 200 pills taken twice a day. The testosterone levels go up and then they drop. And then you take it again and it goes up and it goes down. And the symptomatic response is excellent.
For Kisotrex, the usual starting dose that most urologists are using now is 400 BID. So it's two of the 200 pills taken twice a day. The testosterone levels go up and then they drop. And then you take it again and it goes up and it goes down. And the symptomatic response is excellent.
And one of the interesting things is because the body goes back to, because there's not the sustained high testosterone level, some of the side effects or the things that we worried about with testosterone don't happen as much. So there's less suppression of the gonadotropins LH and FSH, which are the hormones that act on the testicle to make sperm.
And one of the interesting things is because the body goes back to, because there's not the sustained high testosterone level, some of the side effects or the things that we worried about with testosterone don't happen as much. So there's less suppression of the gonadotropins LH and FSH, which are the hormones that act on the testicle to make sperm.
And one of the interesting things is because the body goes back to, because there's not the sustained high testosterone level, some of the side effects or the things that we worried about with testosterone don't happen as much. So there's less suppression of the gonadotropins LH and FSH, which are the hormones that act on the testicle to make sperm.
So I don't know this has been shown yet, but anecdotally, testicular size doesn't shrink the way it does with some other products. And I think we're waiting on some fertility studies. But the early indications are is that this, we used to say testosterone always is, you can't do it if you're trying to make babies.
So I don't know this has been shown yet, but anecdotally, testicular size doesn't shrink the way it does with some other products. And I think we're waiting on some fertility studies. But the early indications are is that this, we used to say testosterone always is, you can't do it if you're trying to make babies.
So I don't know this has been shown yet, but anecdotally, testicular size doesn't shrink the way it does with some other products. And I think we're waiting on some fertility studies. But the early indications are is that this, we used to say testosterone always is, you can't do it if you're trying to make babies.
So it's going to drop your sperm counts to zero or close to it if you're on injections or pellets. Should recover, but not always. But with the oral, I think that's going to turn out to be not as common a problem. So that may be very, very helpful.
So it's going to drop your sperm counts to zero or close to it if you're on injections or pellets. Should recover, but not always. But with the oral, I think that's going to turn out to be not as common a problem. So that may be very, very helpful.
So it's going to drop your sperm counts to zero or close to it if you're on injections or pellets. Should recover, but not always. But with the oral, I think that's going to turn out to be not as common a problem. So that may be very, very helpful.
Is that more or less accurate? What an interesting idea. So the question I think you're asking about is what about trying to give them a little daily boost without really changing much? I think that's a very interesting idea. I'm not aware that anybody is trying that yet or has reported any data on it, but it's a very interesting idea.