Dr. Abud Bakri

training wheel effect when it comes to GLP-1s.

Okay, you come to us, you're a patient, you want to use GLP-1s.

We'll give you a lowest dose as possible that has an effect for you, GLP-1, in conjunction with lifestyle modification, dietary advice, exercise programs, et cetera, et cetera, et cetera.

And then hopefully peel away those training wheels or keep them on if you need them until we get to the end point that we want.

Now,

When people do it that way, I don't hear a lot of these effects anecdotally from Berkeley patients that we hear about online where people are like, oh, I'm depressed.

I hate my life from these drugs.

And the question is, are they just, you know, a lot of people have low blood pressure from these drugs because they're not, you know, consuming enough electrolytes or enough food, period.

Because like some people will take a mega dose of these drugs and end up not eating like –

A day goes by, they've eaten one meal.

That's not conducive to feeling good.

The reason people are obese in the first place is because eating is such a pleasurable experience for humans and a social experience, et cetera, et cetera.

The other thing is if you're not eating with people on the same table, are you having less of that socialization aspect?

A lot of times you meet up to eat or drink or whatever it may be.

I'm very curious when it comes to the cognitive effects.

Is it from the drug directly interacting with the receptors in the brain when we've seen that the right amount of dose decreases inflammation in the brain?

Or is it because of the social aspects of the drug changing the way you behave and therefore leading to negative appetite?

Yeah, and we know the literature shows that people now are having less alcohol cravings from this.

It might be changing the way the dopaminergic signaling is happening in the brain, which is concerning, right?

Because a lot of people will be stacking this with, you know, ADHD medications.