Dr. Adeel Khan
speaker
165 appearances
1 recordings
1 series
first heard Nov 2024
last heard Nov 2024
Dr. Adeel Khan’s voice in public audio — every appearance, attributed to the second.
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And so that takes years of training. And then on top of that, you have to know which products to use. So I think people don't realize this is a very specialized field. It's not like anyone can just do it despite a lot of people just offering stem cells. You know what I mean? A lot of people are like, yeah, I do stem cells.
It's like, well, you can't, it's not, it's not just like, you can't just like do that. It's like doing, to me, it's like almost doing surgery. It's like, I don't just do surgery just for the sake of it. You know?
Yeah. And so the image guidance is very key to it. And the results for musculoskeletal conditions, chronic pain, even neuropathic pain has been very consistent, meaning the only patients that I find that don't get better usually just need a second treatment or sometimes a third in very rare cases. So it's just a dosing thing.
We don't know the perfect dosing for everyone, but we're starting to learn that more and more
Cause some people respond great to one treatment and some people need two treatments and we don't really know why.
Yeah. So I work with a company called mini circle and mini circle has the world's first reversible plasma gene therapy. So what that means is it's basically a way for us to transmit any gene of interest up to a certain size to your body. So for example,
If there's a gene like phallostatin, which is a bioidentical peptide hormone in your body, and we want your body to produce more of that, we can put it onto this mini circle vector. We call it mini circle because literally it's like a circular strand of DNA that
and you insert that phallostatin gene onto there and then you can inject it and then that will transmit it to your cell and tell your cell hey your cell will now read that instructions and then it'll say hey i need to produce more phallostatin and then phallostatin goes into the blood and you raise your phallostatin levels and that has all these downstream benefits which we can talk about in a second but the vector is what people need to obviously is you know probably being like holy what was what is he talking about right the vector is scary you're like what are you doing like
Yeah, exactly. Are you modifying my DNA?
Yeah, exactly. So it's not as advanced as CRISPR, which is kind of the gene editing technology where you're actually cutting out different strands of DNA and kind of putting them back together. This isn't as complicated as that. It's not as powerful as that either, but it is still a form of genetic modification because We are inserting a foreign DNA into your body.
Where does that foreign DNA come from? It comes from E. coli. So we're not injecting bacteria into your body, but we're injecting something called plasmid. The plasmid is kind of think of it like exchanging cards with people. It's how bacteria exchange information. So we're isolating that plasmid from the E. coli, and then we're using that as a vector.
So plasmids have been around in microbiology for two, three decades. They're not new, but the new breakthrough was just getting the plasmid to not shut off. Because normally when you put a plasmid in the human body, your cell does something called transient silencing, which just says, hey, this doesn't belong here. I'm going to shut you off. And then it just shuts it off.
And then but we figured out a way for it to keep remain on specifically to express whatever gene of interest we want, which obviously are longevity genes. We're not going to put something in your body that's not useful. We're going to put something in your body that's going to have some real longevity benefits. And polystatin has been studied again for two decades.
Polystatin is something your body makes. It's basically a way for your body to put on more muscle because the higher your polystatin, the lower your myostatin. which is basically imagine the brakes on your muscle. And so if you take the brakes off a little bit, it's not like you're going to get jacked like the anabolic steroids, but it will make it a little bit easier to put on muscle.
But much more importantly, and this is why I like polystatin, it's very anti-catabolic. Because as you get older, especially after age 60, your catabolism increases exponentially.
There's anabolism and catabolism. Anabolism is building more tissue. Catabolism is what happens with aging, which is loss of tissue. We actually lose, I forgot the exact percentage, but we lose some like, you know, very large percentage of our total tissue mass as we age. And that's loss of mitochondria, that's loss of muscle, that's loss of bone density. So we lose a lot of tissue as we age.
And so if you can maintain as much tissue as possible, that's going to be a a net positive thing, and especially muscle tissue, because muscle tissue is the most metabolically active. It has all these protective cytokines that are released called myokines that turn off tumor suppressors that help prevent cancer, help with diabetes. I'm sure most people know about the benefits of muscle.
and anything we can do to help preserve that, I think it's going to have a net positive effect on your health. There's obviously a lot of people get concerned. They're like, how do you know this is a hundred percent safe? Because it's new. It is new, obviously. And I'm not saying there's not enough long-term data to know, is it going to do something to you 20 years from now?
We can't say that for sure, but what I can say, and the reason I'm a believer in it and the reason I've done it for myself and obviously patients and Many, I've injected hundreds of people with it.
And the reason is because, and the reason patients like it too, is because the net positive of having more muscle and having reduced systemic inflammation, which is what false statin does, to me is going to outweigh any theoretical risk that maybe we don't know about. But I think it's unlikely anyway, because we understand how false statin works.
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