Dr. Adeel Khan
speaker
165 appearances
1 recordings
1 series
first heard Nov 2024
last heard Nov 2024
Dr. Adeel Khan’s voice in public audio — every appearance, attributed to the second.
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That's exactly right. And this is one of the drivers, but that's a great, a great summary. Yes.
I mean, what if the gene, what if the product, like some of the risks, for example, in theory could be, what if, what if the vector that we're using migrates? What if it goes somewhere we don't want it to go? But plasmid vectors are very well studied and very well documented.
kind of documented how they work and they have a very high, you know, they have a high safety profile because they're very inert, meaning they don't stimulate your immune system. They don't cause they don't have any, you know, known serious risks, but there are vectors, for example, so people can understand like what is with the vector.
For example, when they use the COVID vaccine, they use something called the lipid nanoparticle vector LPV. But the LPV, if you read about LPV, the vector that they use, unfortunately, can migrate. And that's why some people get myocarditis or pericarditis. And the vector can also be immunogenic. So that's why it stimulates some people's immune system. And that's why they get autoimmune conditions.
And that's why we know now that the vaccine actually has some harm, more than we probably thought when it first came out. So basically the plasmid vector, though, as compared to like a lipid nanoparticle vector is a lot safer just for comparison.
Yeah, so Clotho is a really, really interesting peptide because
the the word itself comes from the greek of saying the one who controls the threads of life which is a bit dramatic but basically but basically it's like whoa holy what does this clotho do does it control my life yeah well yeah what they thought what they realized they found this accidentally in some animal research and they found out that animals that had higher levels of clotho lived 30 longer and then they've seen similar data in humans of people who have higher levels of clotho naturally
not only live longer but they're protected against dementia even if they have the echo e4 gene which is super interesting and then it can actually help with kidney chronic kidney disease too so the two levels where most of your clotho is produced is your brain and your kidneys and so those are the two main medical indications which culto is being very
very like looked at like there's a lot of research going on right now and there's a lot of biotech companies looking at cocoa but our platform i believe has the most applicability just because of the ease of use and obviously being able to just give it same technology through a plasmid vector which is just an injection in your arm or your stomach and then optimizing your Clotho levels.
But Clotho is definitely more high risk than Phallostatin because you don't want your Clotho levels to go too high either. If Phallostatin levels go too high, it doesn't really have any harm. It just saturates and there's not really much that happens. But Clotho,
If your colto levels go too high, it can cause your PTH to go down, and it can kind of mess up your hormonal system, and there could actually be other detrimental side effects. So colto is definitely exciting, but I think we're still at least a year, a year and a half away after the clinical trial that we're starting now before we can start offering it to people.
I'm going to be doing it on myself actually next month, so I'll keep you posted.
PTH, parathyroid hormone.
So you have to monitor it. So you have to do blood work for that. Yeah.
So It activates Wnt genes, which are these regenerative pathways. The Wnt gene pathway is kind of well known for being one of the more important ones that a lot of different regenerative molecules work on. And Clotho helps with that too. So it can facilitate regeneration and repair as well. And it can also, in terms of helping with neuronal death.
So there's something called the integrative stress response, which is what your neurons, when they are under stress, they have this stress response called ISR. And Clotho can help to mitigate that so there's less neuronal death. And that's why it can help with various... That's why there's so much interest for so many different neurodegenerative conditions.
Yeah. So the costs will come down and then I believe in the net really like not, we're not talking like 10 years, we're talking within the next five years because we're very close to this kind of automation and of manufacturing. There's a company in, Silicon Valley that actually just started. And they're doing well. They basically figured out how to automate cell manufacturing using robotics.
And so using that plus bioreactors, which allow you to grow a lot more cells a lot quicker, will significantly reduce the cost of manufacturing these cells. And obviously, if the cost of manufacturing goes down, then the cost of the consumer goes down.
Yeah. And so that's, so that's, that's the first thing. And then the, the, the second thing is. there's economies of scale, which just means as more people do it and there's more demand, then obviously you can lower the pricing as, as there's going to be more people who are willing to do this type of treatment at a lower price point.
And that's one of the things, you know, I'm at, I'm very adamant about making this stuff accessible to the average person. And the only way that's going to happen, as you, as you just said, there has to be early adopters, right? You bought a Mac in 1988 and probably not many people had a Mac back then. So it's like, Uh, but there's going to be early adopters for every technology.
Showing 121–140 of 165 · page 7 of 9
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