Dr. Andrew Huberman

reductions in dopamine transmission in the brain.

So things that increase the catecholamines that we talked about earlier.

This could be pharmacology, of course, but it doesn't have to be pharmacology.

It could be anything that increases the catecholamines.

And we talk about this on the podcast.

We have zero cost protocols that you don't have to sign up for.

You can just go to our website and go to dopamine regulation and it will list out ways to increase the catecholamines through zero cost and very low cost ways.

are known to improve working memory.

Working memory, of course, the capacity to maintain a string of numbers or information for sake of kind of immediate goals, but not information that's passed to the longer term memory.

So that's different than neurodegeneration.

That's simply reductions in the amount of neuromodulators like dopamine being deployed as we get older.

So modulating dopamine through healthy, ideally, means

But I do think we are going to see an increase in the use of selective pharmacology for this purpose.

And here I'm not recommending anyone do drugs or take drugs, prescription or otherwise.

But it does seem that certain compounds like nicotine, believe it or not, even though it increases vasoconstriction and blood pressure,

can offset some of the age-related reductions in dopaminergic and cholinergic acetylcholine, cholinergic transmission.

And, you know, you don't want to smoke, vape, dip, or snuff.

I'm not even recommending people take Zin patches, but I think there is some use cases for nicotine, provided you're doing it with, you know, your physician knows and you're not getting into blood pressure, dangerous blood pressure problems,

range or supplementation with choline donors and things of that sort to increase acetylcholine and dopamine.

Some people are starting to take things like modafinil and Adderall in older age.